ID A0A2K6SKP2_SAIBB Unreviewed; 1543 AA.
AC A0A2K6SKP2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Rho guanine nucleotide exchange factor 12 {ECO:0000313|Ensembl:ENSSBOP00000007952.1};
GN Name=ARHGEF12 {ECO:0000313|Ensembl:ENSSBOP00000007952.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000007952.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000007952.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_003923639.1; XM_003923590.2.
DR STRING; 39432.ENSSBOP00000007952; -.
DR Ensembl; ENSSBOT00000024710.1; ENSSBOP00000007952.1; ENSSBOG00000020565.1.
DR GeneID; 101040423; -.
DR KEGG; sbq:101040423; -.
DR CTD; 23365; -.
DR GeneTree; ENSGT00940000157662; -.
DR OMA; QSEYPMI; -.
DR OrthoDB; 2875542at2759; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13390; PH_LARG; 1.
DR CDD; cd08754; RGS_LARG; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR037801; ARHGEF12_PH.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR037884; LARG_RGS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 72..136
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 786..976
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1018..1131
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..596
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1181..1202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1543 AA; 173123 MW; 8A2CA85E3CAFF4C1 CRC64;
MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERIA SHDFDPTDSS SKKTKSSSEE
SRSEIYGLVQ RCVIIQKDDN GFGLTVSGDN PVFVQSVKED GAAMRAGVQT GDRIIKVNGT
LVTHSNHLEV VKLIKSGSYV ALTVQGRPPG SPQIPLADSE VEPSVIGHMS PIMTSPHSPG
ASGNMERITS PVLMGEENNV VHNQKVEILR KMLQKEQERL QLLQEDYNRT PAQRLLKEIQ
EAKKHIPQLQ EQLSKATGSA QDGAVVTPSR PLGDTLTVSE AEADPGDGLG RTDCSSGDAS
RPSSDNADSP KSGPKERIYL EENPEKSETI QDTDTQSLVG SPSTRIAPHI IGAEDDDFGT
EHEQINGQCS CFQSIELLKS RPAHLAVFLH HVVSQFDPAT LLCYLYSDLY KHTNSKETRR
IFLEFHQFFL DRSAHLKVSV PDEMSVDLEK RRPELIPEDL HRHYIQTMQE RVHPEVQRHL
EDFRQKRSMG LTLAESELTK LDAERDKDRL TLEKERTCAE QIVAKIEEVL MTAQAVEEDK
SSTMQYVILM YMKHLGVKVK EPRNLEHKRG RIGFLPKIKQ SMKKDKEGEE KGKRRGFPSI
LGPPRRPSRH DNSAIGRAME LQKARHPKHL STPLSVSPEP QDSAKLRQSG LANEGTDTGY
LPASMSSLAS GASFSQEGGK ENDTGSKQVG ETPAPGDTLD GTPRTLNTVF DFPTPPLDQV
QEEECEVERV TEHGTPKPFR KFDSVAFGES QSEDEQFEND LETDPPNWQQ LVSREVLLGL
KPCEIKRQEV INELFYTERA HVRTLKVLDQ VFYQRVSREG ILSPSELRKI FSNLEDILQL
HIGLNEQMKA VRKRNETSVI DQIGEDLLTW FSGPGEEKLK HAAATFCSNQ PFALEMIKSR
QKKDSRFQTF VQDAESNPLC RRLQLKDIIP TQMQRLTKYP LLLDNIAKYT EWSTEREKVK
KAADHCRQIL NYVNQAVKEA ENKQRLEDYQ RRLDTSSLKL SEYPNVEELR NLDLTKRKMI
HEGPLVWKVN RDKTIDLYTL LLEDILVLLQ KQDDRLVLRC HSKILASTAD SKHTFSPVIK
LNTVLVRQVA TDNKALFVIS MSDNGAQIYE LVAQTVSEKT VWQDLICRMA ASVKEQSTKP
IPLPQSPPGE GDNDEEDPSK LKEEQHGISV TGLQSPDRDL GLESTLMSSK PQSHSLSTSG
KSEVRDLFVA ERQFAKEQHP DGTLKETGED YQITIPDSHL PISEERWALD ALRNLGLLKQ
LLVQQLGLAE KSTQEDWQHF PRYRTASQGA QTDTVIQNSE NIRAYHSSEG HLPFRTGTGD
IATCYSPRTS TESSAPRDSV VLAPQDSQAS NILVMDHMIM TPEMPTTEPE GGLDDSGEHF
FDAREAHSDE NPSEGDGVVN KEEKEINLRI SGNYLILDGY DTVQESSTDE EVASSLTLQP
VTGISAVDST HQQQHSPQNA HSDGVVSPFT PEFLVQQRWG AMEDSCFEIQ SPSSCADSQS
QIMEYIHKIE ADLEHLKKVE ESYTILCQRL AGSALTDKHS DKS
//
