ID A0A2K6SNG2_SAIBB Unreviewed; 316 AA.
AC A0A2K6SNG2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Helt bHLH transcription factor {ECO:0000313|Ensembl:ENSSBOP00000008934.1};
GN Name=HELT {ECO:0000313|Ensembl:ENSSBOP00000008934.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000008934.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000008934.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A2K6SNG2; -.
DR STRING; 39432.ENSSBOP00000008934; -.
DR Ensembl; ENSSBOT00000025696.1; ENSSBOP00000008934.1; ENSSBOG00000021368.1.
DR GeneTree; ENSGT00940000160388; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0021858; P:GABAergic neuron differentiation in basal ganglia; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0001967; P:suckling behavior; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF8; HAIRY AND ENHANCER OF SPLIT-RELATED PROTEIN HELT; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 54..142
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 164..199
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
SQ SEQUENCE 316 AA; 34966 MW; 65259ED5C4EA7645 CRC64;
MSDKLKERKV SRLSPSGTCA LVVEASDSPT LYLAGPMAGT WPHGTLRLEE SRVRTPVSHK
VIEKRRRDRI NRCLNELGKT VPMALAKQPQ AALAQIRSRA HSLVLSRSTV PTQQGLFLLL
QSSGKLEKAE ILEMTVQYLR ALHSADFPRG REKAELLAEF ANYFHYGYHE CMKNLVHYLT
TVERMETKDT KYARILAFLQ SKSRLGAEPA FQPLGSLPEP DFSYQLHPAG PEFAGHSPGE
AAVFPQGSGP GSFPWPPGAA RSPYLPSAAV PLPSPAQQHS PFLTPVQCLD RHYLNRIGHA
HTNALNLHTP QHPPVL
//
