ID   A0A2K6SUG2_SAIBB        Unreviewed;       490 AA.
AC   A0A2K6SUG2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Prostaglandin-endoperoxide synthase 1 {ECO:0000313|Ensembl:ENSSBOP00000011025.1};
GN   Name=PTGS1 {ECO:0000313|Ensembl:ENSSBOP00000011025.1};
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000011025.1, ECO:0000313|Proteomes:UP000233220};
RN   [1] {ECO:0000313|Ensembl:ENSSBOP00000011025.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}. Microsome membrane
CC       {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004174}.
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DR   RefSeq; XP_010334171.1; XM_010335869.1.
DR   AlphaFoldDB; A0A2K6SUG2; -.
DR   GlyCosmos; A0A2K6SUG2; 2 sites, No reported glycans.
DR   Ensembl; ENSSBOT00000027805.1; ENSSBOP00000011025.1; ENSSBOG00000022314.1.
DR   GeneTree; ENSGT00390000010743; -.
DR   OrthoDB; 1086441at2759; -.
DR   UniPathway; UPA00662; -.
DR   Proteomes; UP000233220; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR   GO; GO:0004666; F:prostaglandin-endoperoxide synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd09816; prostaglandin_endoperoxide_synthase; 1.
DR   Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   PANTHER; PTHR11903; PROSTAGLANDIN G/H SYNTHASE; 1.
DR   PANTHER; PTHR11903:SF6; PROSTAGLANDIN G_H SYNTHASE 1; 1.
DR   Pfam; PF03098; An_peroxidase; 1.
DR   PRINTS; PR00457; ANPEROXIDASE.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR   PROSITE; PS50292; PEROXIDASE_3; 1.
PE   4: Predicted;
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW   Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT   ACT_SITE        97
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-1"
FT   ACT_SITE        275
FT                   /note="For cyclooxygenase activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-1"
FT   BINDING         10
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
FT   BINDING         278
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ   SEQUENCE   490 AA;  56033 MW;  BC6DC6617FC8A898 CRC64;
     MLMRLVLTVR SNLIPSPPTY NAAHDYISWE SFSNVSYYTR ILPSVPKDCP TPMGTKGKKQ
     LPDAQLLARR FLLRRKFIPD PQGTNLMFAF FAQHFTHQFF KTSGKMGPGF TKALGHGVDL
     GHIYGDNLER QYQLRLFKDG KLKYQVLDGE MYPPSVEEAP VLMRYPRGIP PQSQMAVGQE
     VFGLLPGLML YATLWLREHN RVCDLLKAEH PTWGDEQLFQ TTRLILIGET IRIVIEEYVQ
     QLSGYFLQLK FDPELLFGVQ FQYRNRIALE FNQLYHWHPL MPDSFKVGSR EYSYEQFLFN
     TSMLVDYGVE ALVDAFSRQS AGRIGGGRNM DHHVLHVAVD VIRESRELRL QPFNEYRKRF
     GMKPYTSFQE LVGEKEMAAE LEELYGDIDA LEFYPGLLLE KCHPNSIFGE SMIEIGAPFS
     LKGLLGNPIC SPEYWKPSTF GGEMGFNIVK TATLKKLVCL NTKTCPYVSF RVPGGSQDEG
     PAVERPSTEL
//