ID A0A2K6SUX3_SAIBB Unreviewed; 221 AA.
AC A0A2K6SUX3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Toll/interleukin-1 receptor domain-containing adapter protein {ECO:0000256|PIRNR:PIRNR037750};
DE Short=TIR domain-containing adapter protein {ECO:0000256|PIRNR:PIRNR037750};
GN Name=TIRAP {ECO:0000313|Ensembl:ENSSBOP00000011178.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000011178.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000011178.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Adapter involved in the TLR2 and TLR4 signaling pathways in
CC the innate immune response. {ECO:0000256|PIRNR:PIRNR037750}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR037750}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037750}. Cell
CC membrane {ECO:0000256|PIRNR:PIRNR037750}. Membrane
CC {ECO:0000256|PIRNR:PIRNR037750}.
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DR RefSeq; XP_010332680.1; XM_010334378.1.
DR STRING; 39432.ENSSBOP00000011176; -.
DR Ensembl; ENSSBOT00000027956.1; ENSSBOP00000011176.1; ENSSBOG00000022406.1.
DR Ensembl; ENSSBOT00000027958.1; ENSSBOP00000011178.1; ENSSBOG00000022406.1.
DR GeneTree; ENSGT00510000048428; -.
DR OMA; RWKRKYD; -.
DR OrthoDB; 5392575at2759; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005080; F:protein kinase C binding; IEA:Ensembl.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR GO; GO:0035663; F:Toll-like receptor 2 binding; IEA:UniProtKB-UniRule.
DR GO; GO:0035662; F:Toll-like receptor 4 binding; IEA:UniProtKB-UniRule.
DR GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0032738; P:positive regulation of interleukin-15 production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0034137; P:positive regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
DR GO; GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0035665; P:TIRAP-dependent toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017279; Tol-interleuk_rcpt_adapt_Tirap.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR22662; TIRAP; 1.
DR PANTHER; PTHR22662:SF0; TOLL_INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN; 1.
DR Pfam; PF13676; TIR_2; 1.
DR PIRSF; PIRSF037750; TIR_Tirap; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR037750};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037750};
KW Immunity {ECO:0000256|PIRNR:PIRNR037750};
KW Inflammatory response {ECO:0000256|PIRNR:PIRNR037750};
KW Innate immunity {ECO:0000256|PIRNR:PIRNR037750};
KW Membrane {ECO:0000256|PIRNR:PIRNR037750};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 84..213
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 221 AA; 24007 MW; 64FAC7BC3036DE48 CRC64;
MASSPSLPAP GSRPKKPLGK MADWFRQTLL KKPKKMPDSS ESVPSDASQP TSQNSPVPPS
HSSVTSPSLP PSQESDSSSI RWSKDYDVCV CHSEEDLVAA QDLVSYLEGS TASLRCFLQF
RDATPGGAIV SELCQALSSS HCRVLLITPG FLQDPWCKYQ MLQALTDAPG AEGRTIPLLS
GLSRAAYPPE LRFMYYVDGR GPDGGFHQVK EAVMRYLQTL S
//
