ID A0A2K6SVR2_SAIBB Unreviewed; 333 AA.
AC A0A2K6SVR2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=tRNA-specific adenosine deaminase 2 {ECO:0000256|ARBA:ARBA00019216};
DE EC=3.5.4.33 {ECO:0000256|ARBA:ARBA00012740};
DE AltName: Full=Deaminase domain-containing protein 1 {ECO:0000256|ARBA:ARBA00033441};
DE AltName: Full=tRNA-specific adenosine-34 deaminase subunit ADAT2 {ECO:0000256|ARBA:ARBA00031817};
GN Name=ADAT3 {ECO:0000313|Ensembl:ENSSBOP00000011476.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000011476.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000011476.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Probably participates in deamination of adenosine-34 to
CC inosine in many tRNAs. {ECO:0000256|ARBA:ARBA00002255}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA +
CC NH4(+); Xref=Rhea:RHEA:43168, Rhea:RHEA-COMP:10373, Rhea:RHEA-
CC COMP:10374, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.33;
CC Evidence={ECO:0000256|ARBA:ARBA00001103};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC family. ADAT3 subfamily. {ECO:0000256|ARBA:ARBA00038160}.
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DR AlphaFoldDB; A0A2K6SVR2; -.
DR SMR; A0A2K6SVR2; -.
DR STRING; 39432.ENSSBOP00000011476; -.
DR Ensembl; ENSSBOT00000028259.1; ENSSBOP00000011476.1; ENSSBOG00000022564.1.
DR GeneTree; ENSGT00390000010706; -.
DR OMA; QHWPTSF; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0052717; F:tRNA-specific adenosine-34 deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0002100; P:tRNA wobble adenosine to inosine editing; IEA:InterPro.
DR CDD; cd01285; nucleoside_deaminase; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR InterPro; IPR002125; CMP_dCMP_dom.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR028883; tRNA_aden_deaminase.
DR PANTHER; PTHR11079; CYTOSINE DEAMINASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11079:SF156; INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED; 1.
DR Pfam; PF14437; MafB19-deam; 1.
DR SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 176..318
FT /note="CMP/dCMP-type deaminase"
FT /evidence="ECO:0000259|PROSITE:PS51747"
SQ SEQUENCE 333 AA; 36263 MW; F98BD9C331C06E1A CRC64;
SAWLRMEPAS GLLEQLQRTE AGSPEPEPTP WQALPVLSEQ QAGDVELVLA YAAPVLDKRQ
TSRLLKEVSA LHPLAAQPHL KRVRPSRDAS SPHALEMLLC LAGPASGPRS LAELLPRPAV
DTSGLGQPFL VPVPARPPLT RSQFEEARAH WPTSFHEDKQ VTSALAGRLF STQERAAMQS
HMERAVRAAR WAAARGLSAA SPLLHAVMVC VDLVARGQGR GTYDFAPFPA CSFAPATAPH
GVRAGAVRKL DTDEDGLPYV CTGYDLYVTR EPCAMCAMAL VHSRILRVFY GAPSPDGALG
TRFRIHARPD LNHRFQVFRG VLEEQCLRLD PDT
//
