ID A0A2K6SYJ0_SAIBB Unreviewed; 413 AA.
AC A0A2K6SYJ0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cathepsin F {ECO:0000313|Ensembl:ENSSBOP00000012430.1};
GN Name=CTSF {ECO:0000313|Ensembl:ENSSBOP00000012430.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000012430.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000012430.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR AlphaFoldDB; A0A2K6SYJ0; -.
DR STRING; 39432.ENSSBOP00000012430; -.
DR Ensembl; ENSSBOT00000029220.1; ENSSBOP00000012430.1; ENSSBOG00000023016.1.
DR GeneTree; ENSGT00940000162141; -.
DR OMA; RSATPFW; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 1.10.287.2250; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF444; CATHEPSIN F; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 116..173
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 200..411
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 413 AA; 45706 MW; 0499964643B37BFD CRC64;
AGQGSLYSLE ATLEEPPCND PLVCQLPVSK KTLLCSFEVL DELGKHVLLR KDCGPVDTKV
PGAGEPKSAF TQGSVMISSL SQPHPDNGNE TFSPVFSLLN EDPLPQDLTV KMASIFRNFV
ITYNRTYESK EEAQWRLSIF AHNMVRAQKI QALDRGTAQY GVTKFSDLTE EEFRTIYLNP
LLREEPGKKM KQAKSVGDLA PPEWDWRSKG AVTKVKDQGM CGSCWAFSVT GNVEGQWFLN
QGTLLSLSEQ ELLDCDKIDK ACMGGLPSSA YSAIKNLGGL ETEDDYSYRG HMQACSFSPE
KAKVYINDSV ELSQNEQKLA AWLAKRGPIS VAINAFGMQF YRHGISRPLR PLCSPWLIDH
AVLLVGYGNR SDIPFWAIKN SWGTDWGEKG YYYLHRGSGA CGVNTMASSA VVD
//
