ID A0A2K6T2K0_SAIBB Unreviewed; 3814 AA.
AC A0A2K6T2K0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Transformation/transcription domain associated protein {ECO:0000313|Ensembl:ENSSBOP00000013826.1};
GN Name=TRRAP {ECO:0000313|Ensembl:ENSSBOP00000013826.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000013826.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000013826.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
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DR Ensembl; ENSSBOT00000030622.1; ENSSBOP00000013826.1; ENSSBOG00000022151.1.
DR GeneTree; ENSGT00390000017961; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0048584; P:positive regulation of response to stimulus; IEA:UniProt.
DR GO; GO:0080135; P:regulation of cellular response to stress; IEA:UniProt.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 2647..3230
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3455..3778
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3782..3814
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 490..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2024..2044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2498..2533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..525
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2028..2044
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3814 AA; 432669 MW; DE25DA0D1E48D8AD CRC64;
MAFVATQGAT VVDQTTLMKK YLQFVAALTD VNTPDETKLK MMQEVSENFE NVTSSPQYST
FLEHIIPRFL TFLQDGEVQF LQEKPAQQLR KLVLEIIHRI PTNEHLRPHT KNVLSVMFRF
LETENEENVL ICLRIIIELH KQFRPPITQE IHHFLDFVKQ IYKELPKVVN RYFENPQVIP
ENTVPPPEMV GMITTIAVKV NPEREDSETR THSIIPRGSL SLKVLAELPI IVVLMYQLYK
LNIHNVVAEF VPLIMNTIAI QVSSQARQHK LYNKELYADF IAAQIKTLSF LAYIIRIYQE
LVTKYSQQMV KGMLQLLSNC PAETAHLRKE LLIAAKHILT TELRNQFIPC MDKLFDESIL
IGSGYTARET LRPLAYSTLA DLVHHVRQHL PLSDLSLAVQ LFAKNIDDES LPSSIQTMSC
KLLLNLVDCI RSKSEQESGN GRDVLMRMLE VFVLKFHTIA RYQLSAIFKK CKPQSELGAV
EATLPGVPTA PAAPGPAPSP APVPAPAPPP PPPPPATPVT PAPVPPFEKQ GEKDKEDKQT
FQVTDCRSLV KTLVCGVKTI TWGITSCKAP GEAQFIPNKQ LQPKETQIYI KLVKYAMQAL
DIYQVQIAGN GQTYIRVANC QTVRMKEEKE VLEHFAGVFT MMNPLTFKEI FQTTVPYMVE
RISKNYALQI VANSFLANPT TSALFATILV EYLLDRLPEM GSNVELSNLY LKLFKLVFGS
VSLFAAENEQ MLKPHLHKIV NSSMELAQTA KEPYNYFLLL RALFRSIGGG SHDLLYQEFL
PLLPNLLQGL NMLQSGLHKQ HMKDLFVELC LTVPVRLSSL LPYLPMLMDP LVSALNGSQT
LVSQGLRTLE LCVDNLQPDF LYDHIQPVRA ELMQALWRTL RNPADSISHV AYRVLGKFGG
SNRKMLKESQ KLHYVVTEVQ GPSITVEFSD CKASLQLPME KAIETALDCL KSANTEPYYR
RQAWEVIKCF LVAMMSLEDN KHALYQLLAH PNFTEKTIPN VIISHRYKAQ DTPARKTFEQ
ALTGAFMSAV IKDLRPSALP FVASLIRHYT MVAVAQQCGP FLLPCYQVGS QPSTAMFHSE
ENGSKGMDPL VLIDAIAICM AYEEKELCKI GEVALAVIFD VASIILGSKE RACQLPLFSY
IVERLCACCY EQAWYAKLGG VVSIKFLMER LPLTWVLQNQ QTFLKALLFV MMDLTGEVSN
GAVAMAKTTL EQLLMRCATP LKDEERAEEI VAAQEKSFHH VTHDLVREVT SPNSTVRKQA
MHSLQVLAQV TGKSVTVIME PHKEVLQDMV PPKKHLLRHQ PANAQIGLME GNTFCTTLQP
RLFTMDLNVV EHKVFYTELL NLCEAEDSAL TKLPCYKSLP SLVPLRIAAL NALAACNYLP
QSREKIIAAL FKALNSTNSE LQEAGEACMR KFLEGATIEV DQIHTHMRPL LMMLGDYRSL
TLNVVNRLTS VTRLFPNSFN DKFCDQMMQH LRKWMEVVVI THKGGQRSDG NESISECGRC
PLSPFCQFEE MKICSAIINL FHLIPAAPQT LVKPLLEVVM KTERAMLIEA GSPFREPLIK
FLTRHPSQTV ELFMMEATLN DPQWSRMFMS FLKHKDARPL RDVLAANPNR FITLLLPGGA
QTAVRPGSPS TSTMRLDLQF QAIKIISIIV KNDDSWLASQ HSLVSQLRRV WVSETFQERH
HKENMAATNW KEPKLLAYCL LNYCKRNYGD IELLFQLLRA FTGRFLCNMT FLKEYMEEEI
PKNYSITQKR ALFFRFVDLN DPNFGDELKA KVLQHILNPA FLYSFEKGEG EQLLGPPNPE
GDNPESITSV FITKVLDPEK QADMLDSLRI YLLQYATLLV EHAPHHIHDN NKNRNSKLRR
LMTFAWPCLL SKACVDPACK YSGHLLLAHI IAKFAIHKKI VLQVFHSLLK AHAMEARAIV
RQAMAILTPA VPARMEDGHQ MLTHWTRKII VEEGHTVPQL VHILHLIVQH FKVYYPVRHH
LVQHMVSAMQ RLGFTPSVTI EQRRLAVDLS EVVIKWELQR IKDQQPDSDM DPNSSGEGVN
SVSSSIKRGL SVDSAQEVKR FRTATGAISA VRSCASVGAV SEMPALTRMN YMWSKSELKL
QWFDKLLMTV EQPNQVNYGN ICTGLEVLSF LLTVLQSPAI LSSFKPLQRG IAACMTCGNT
KVLRAVHSLL SRLMSIFPTE PSTSSVASKY EELECLYAAV GKVIYEGLTN YEKATNANPS
QLFGTLMILK SACSNNPSYI DRLISVFMRS LQKMVREHLN PQAASGSTEA TSAGTSELVM
LSLELVKTRL AVMSMEMRKN FIQAILTSLI EKSPDAKILR AVVKIVEEWV KNNSPMAANQ
TPTLREKSIL LVKMMTYIEK RFPEDLELNA QFLDLVNYVY RDETLSGSEL TAKLEPAFLS
GLRCAQPLIR AKFFEVFDNS MKRRVYERLL YVTCSQNWEA MGNHFWIKQC IELLLAVCEK
STPIGTSCQG AMLPSITNVI NLADSHDRAA FAMVTHVKQE PRERENSESK EEDVEIDIEL
APGDQTSTPK TKELSEKDIG NQLHMLTNRH DKFLDTLREV KTGALLSAFV QLCHISTTLA
EKTWVQLFPR LWKILSDRQQ HALAGEISPF LCSGSHQVQR DCQPSALNCF VEAMSQCVPP
IPIRPCVLKY LGKTHNLWFR STLMLEHQAF EKGLSLQIKP KQTTEFYEQE SITPPQQEIL
DSLAELYSLL QEEDMWAGLW QKRCKYSETA TAIAYEQHGF FEQAQESYEK AMDKAKKEHE
RSNASPAIFP EYQLWEDHWI RCSKELNQWE ALTEYGQSKG HINPYLVLEC AWRVSNWTAM
KEALVQVEVS CPKEMAWKVN MYRGYLAICH PEEQQLSFIE RLVEMASSLA IREWRRLPHV
VSHVHTPLLQ AAQQIIELQE AAQINAGLQP TNLGRNNSLH DMKTVVKTWR NRLPIVSDDL
SHWSSIFMWR QHHYQGKPTW SGMHSSSIVT AYENSSQHDP SSNNAMLGVH ASASAIIQYG
KIARKQGLVN VALDILSRIH TIPTVPIVDC FQKIRQQVKC YLQLAGVMGK NECMQGLEVI
ESTNLKYFTK EMTAEFYALK GMFLAQINKS EEANKAFSAA VQMHDVLVKA WAMWGDYLEN
IFVKERQLHL GVSAITCYLH ACRHQNESKS RKYLAKVLWL LSFDDDKNTL ADAVDKYCIG
VPPIQWLAWI PQLLTCLVGS EGKLLLNLIS QVGRVYPQAV YFPIRTLYLT LKIEQRERYK
SDPGPIRATA PMWRCSRIMH MQRELHPTLL SSLEGIVDQM VWFRENWHEE VLRQLQQGLA
KCYSVAFEKS GAVSDAKITP HTLNFVKKLV STFGVGLENV SNVSTMFSSA ASESLARRAQ
ATAQDPVFQK LKGQFTTDFD FSVPGSMKLH NLISKLKKWI KILEAKTKQL PKFFLIEEKC
RFLSNFSAQT AEVEIPGEFL MPKPTHYYIK IARFMPRVEI VQKHNTAARR LYIRGHNGKI
YPYLVMNDAC LTESRREERV LQLLRLLNPC LEKRKETTKR HLFFTVPRVV AVSPQMRLVE
DNPSSLSLVE IYKQRCAKKG IEHDNPISRY YDRLATVQAR GTQASHQVLR DILKEVQSNM
VPRSMLKEWA LHTFPNATDY WTFRKMFTIQ LALIGFAEFV LHLNRLNPEM LQIAQDTGKL
NVAYFRFDIN DATGDLDANR PVPFRLTPNI SEFLTTIGVS GPLTASMIAV ARCFAQPNFK
VDGILKTVLR DEIIAWHKKT QEDTSSPLSA AGQPENMDSQ QLVSLVQKAV TAIMTRLHNL
AQFEGGESKV NTLVAAANSL DNLCRMDPAW HPWL
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