ID   A0A2K6T3J6_SAIBB        Unreviewed;       349 AA.
AC   A0A2K6T3J6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Interferon regulatory factor {ECO:0000256|PIRNR:PIRNR038196};
GN   Name=IRF2 {ECO:0000313|Ensembl:ENSSBOP00000014227.1};
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000014227.1, ECO:0000313|Proteomes:UP000233220};
RN   [1] {ECO:0000313|Ensembl:ENSSBOP00000014227.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038196}.
CC   -!- SIMILARITY: Belongs to the IRF family. {ECO:0000256|PIRNR:PIRNR038196}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_003933897.1; XM_003933848.2.
DR   RefSeq; XP_010342706.1; XM_010344404.1.
DR   RefSeq; XP_010342707.1; XM_010344405.1.
DR   AlphaFoldDB; A0A2K6T3J6; -.
DR   STRING; 39432.ENSSBOP00000014227; -.
DR   Ensembl; ENSSBOT00000031025.1; ENSSBOP00000014227.1; ENSSBOG00000023860.1.
DR   GeneID; 101030226; -.
DR   KEGG; sbq:101030226; -.
DR   CTD; 3660; -.
DR   GeneTree; ENSGT00940000159063; -.
DR   OMA; SSWPPFA; -.
DR   OrthoDB; 3740806at2759; -.
DR   Proteomes; UP000233220; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   CDD; cd00103; IRF; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR019817; Interferon_reg_fac_CS.
DR   InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR   InterPro; IPR017431; IRF1/IRF2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR   PANTHER; PTHR11949:SF22; INTERFERON REGULATORY FACTOR 2; 1.
DR   Pfam; PF00605; IRF; 1.
DR   PIRSF; PIRSF038196; IFN_RF1/2; 1.
DR   PRINTS; PR00267; INTFRNREGFCT.
DR   SMART; SM00348; IRF; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00601; IRF_1; 1.
DR   PROSITE; PS51507; IRF_2; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR038196};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   DNA-binding {ECO:0000256|PIRNR:PIRNR038196};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR038196};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW   Transcription {ECO:0000256|PIRNR:PIRNR038196};
KW   Transcription regulation {ECO:0000256|PIRNR:PIRNR038196};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          5..113
FT                   /note="IRF tryptophan pentad repeat"
FT                   /evidence="ECO:0000259|PROSITE:PS51507"
FT   REGION          117..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          295..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..139
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..328
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   349 AA;  39332 MW;  C4D304FE6C3847B4 CRC64;
     MPVERMRMRP WLEEQINSNT IPGLKWLNKE KKIFQIPWMH AARHGWDVEK DAPLFRNWAI
     HTGKHQPGVD KPDPKTWKAN FRCAMNSLPD IEEVKDKSIK KGNNAFRVYR MLPLSERPSK
     KGKKPKTEKE DRVKHIKQEP VESSLGLSNG VSDLSPEYAV LASAIKNEVD STVNIIVVGQ
     SHLDSNIEDQ EIVTNPPDIC QVVEVTTESD EQPASMSELY PLQISPVSSY AESETTDSVP
     SDEESAEGRP HWRKRNIEGK QYLSNMGIRG PYQLPGMASF VTSSKPDLQV TIKDESRPVP
     YNSSWPPFQD LPLSSSVTQA SSSSRPDRET RASVIKKTSD ITQARVKSC
//