ID A0A2K6T5U5_SAIBB Unreviewed; 2864 AA.
AC A0A2K6T5U5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Teneurin transmembrane protein 4 {ECO:0000313|Ensembl:ENSSBOP00000015010.1};
GN Name=TENM4 {ECO:0000313|Ensembl:ENSSBOP00000015010.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000015010.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000015010.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_010343914.1; XM_010345612.1.
DR STRING; 39432.ENSSBOP00000015010; -.
DR Ensembl; ENSSBOT00000031808.1; ENSSBOP00000015010.1; ENSSBOG00000024234.1.
DR KEGG; sbq:101047606; -.
DR GeneTree; ENSGT01030000234566; -.
DR OrthoDB; 5491728at2759; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032289; P:central nervous system myelin formation; IEA:Ensembl.
DR GO; GO:0048666; P:neuron development; IEA:Ensembl.
DR GO; GO:0031641; P:regulation of myelination; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR011048; Haem_d1_sf.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF9; TENEURIN-4; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF05593; RHS_repeat; 1.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF51004; C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 436..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..436
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 721..753
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 851..882
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 891..926
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 743..752
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 855..865
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 872..881
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 895..905
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 916..925
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2864 AA; 317505 MW; BBE75ACB312AD410 CRC64;
MEPDHSALSA ARTLFVDVEE RGPEAMDVKE RKPYRSLTRR RDAERRYTSS SADSEDGKAP
QKSYSSSETL KAYDQDARLA YGSRVKDMVP QEAEEFCRAG ANFTLRELGL EEVTPPHGTL
YRTDIGLPHC GYSVGAGSDA DMEADTVLSP EHPVRLWGRS TRSGRSSCLS SRANSNLTLT
DTEHENTETG APLHCSSASS TPIEQSPSPP PSPPANESQR RLLGNGVAQP TPDSDSEEEF
VPNSFLVKSG SASLGVAAND HPGGLQNHPR LRTPPPPLSH AHTPNQHHAA SINSLNRGNF
TPRSNPSPAP TDHSLSGEPP AGGTQEPAHA QDNWLLNSNI PLETRNLGKQ PFLGTLQDNL
IEMDILGASR HDGAYGDGHF LFKPGGTSPL FCTTSPGYPL TSSTVYSPPP RPLPRSTFAR
PAFNLKKPSK YCNWKCAALS AIVISATLVI LLAYFVAMHL FGLNWHLQPM EGQMYEITED
TASSWPVPTD VSLYPSGGTG LETPDRKGKG TAEGKPSSFF PDDSFIDSGE IDVGRRASQK
IPPGTFWRSQ VFIDHPVHLK FNVSLGKAAL VGIYGRKGLP PSHTQFDFVE LLDGRRLLTQ
EARSLEGTPR QSRGAVPPSS HETGFIQYLD SGIWHLAFYN DGKESEVVSF LTTAIESVDN
CPSNCYGNGD CISGTCHCFL GFLGPDCGRA SCPVLCSGNG QYMKGRCLCH SGWKGAECDV
PTNQCIDVAC SNHGTCIMGT CICNPGYKGE SCEEVDCMDP TCSGRGVCVR GECHCSVGWG
GTNCETPRAT CLDQCSGHGT FLPDTGLCSC DPSWTGHDCS IEICAADCGG HGVCVGGTCR
CEDGWMGAAC DQRACHPRCA EHGTCRDGKC ECSPGWNGEH CTIAHYLDRV VKEGCPGLCN
GNGRCTLDLN GWHCVCQLGW RGAGCDTSME TACGDSKDND GDGLVDCMDP DCCLQPLCHV
NPLCLGSPDP LDIIQETQVP VSQQNLHSFY DRIKFLVGRD STHIIPRENP FDGGHACVIR
GQVMTSDGTP LVGVNISFVN NPLFGYTVSR QDGSFDLVTN GGISIILRFE RAPFITQEHT
LWLPWDRFFV METIIMRHEE NEIPSCDLSS FARPNPVVSP SPLTSFASSC AEKGPIVPEI
QALQEEISIS GCKMRLSYLS SRTPGYKSVL RISLTHPTIP FNLMKVHLMV AVEGRLFRKW
FAAAPDLSYY FIWDKTDVYN QKVFGLSEAF VSVGYEYESC PDLILWEKRT AVLQGYEIDA
SKLGGWSLDK HHALNIQSGI LHKGNGENQF VSQQPPVIGS IMGNGRRRSI SCPSCNGLAD
GNKLLAPVAL TCGSDGSLYV GDFNYIRRIF PSGNVTNILE LRNKDFRHSH SPAHKYYLTT
DPMSGAVFLS DTNSRRVFKI KSTVVVKDLV KNSEVVAGTG DQCLPFDDTR CGDGGKATEA
TLTNPRGITV DKFGLIYFVD GTMIRRIDQN GIISTLLGSN DLTSARPLSC DSVMDISQVR
LEWPTDLAVN PMDNSLYVLD NNVVLQISEN HQVRIVAGRP MHCQVPGIDH FLLSKVAIHA
TLESATALAV SHNGVLYIAE TDEKKINRIR QVTTSGEISL VAGAPSGCDC KNDANCDCFS
GDDGYAKDAK LNTPSSLAVC ADGELYVADL GNIRIRFIRK NKPFLNTQNM YELSSPIDQE
LYLFDTTGKH LYTQSLPTGD YLYNFTYTGD GDVTLITDNN GNMVNVRRDS TGMPLWLVVP
DGQVYWVTMG TNSALKSVTT QGHELAMMTY HGNSGLLATK SNENGWTTFY EYDSFGRLTN
VTFPTGQVSS FRSDTDSSVH VQVETSSKDD VTITTNLSAS GAFYTLLQDQ VRNSYYIGAD
GSLRLLLANG MEVALQTEPH LLAGTVNPTV GKRNVTLPID NGLNLVEWRQ RKEQARGQVT
VFGRRLRVHN RNLLSLDFDR VTRTEKIYDD HRKFTLRILY DQAGRPSLWS PSSRLNGVNV
TYSPGGHIAG IQRGIMSERM EYDQAGRLTS RIFADGKTWS YTYLEKSVVL LLHSQRQYIF
EFDKNDRLSS VTMPNVARQT LETIRSVGYY RNIYQPPEGN ASVIQDFTED GHLLHTFYLG
TGRRVIYKYG KLSKLAETLY DTTKVSFTYD ETAGMLKTIN LQSEGFTCTI RYRQIGPLID
RQIFRFTEEG MVNARFDYNY DNSFRVTSMQ AVINETPLPI DLYRYDDVSG KTEQFGKFGV
IYYDINQIIT TAVMTHTKHF DAYGRMKEVQ YEIFRSLMYW MTVQYDNMGR VVKKELKVGP
YANTTRYSYE YDADGQLQTV SINDKPLWRY SYDLNGNLHL LSPGNSARLT PLRYDLRDRI
TRLGDVQYKM DEDGFLRQRG GDVFEYNSAG LLIKAYNRAG SWSVRYRYDG LGRRVSSKSS
HGHHLQFFYA DLTSPTKVTH LYNHSSSEIT SLYYDLQGHL FAMELSSGDE FYIACDNIGT
PLAVFSGTGL MIKQILYTAY GEIYMDTNPN FQIIIGYHGG LYDPLTKLVH MGRRDYDVLA
GRWTSPDHEL WKHLSSSNIM PFNLYMFKNN NPISNSQDIK CFMTDVNSWL LTFGFQLHNV
IPGYPKPDMD AMEPSYELIH TQMKTQEWDN SKSILGVQCE VQKQLKAFVT LERFDQLYGS
TITSCQQAPK TKKFASSGSV FGKGVKFALK DGRVTTDIIS VANEDGRRVA AVLNNAHYLE
NLHFTVDGVD THYFVKPGPS EGDLAILGLS GGRRTLENGV NVTVSQINTM LNGRTRRYTD
IQLQYGALCL NTRYGTTLDE EKARVLELAR QRAVRQAWAR EQQRLREGEE GLRAWTEGEK
QQVLSTGRVQ GYDGFFVISV EQYPELSDSA NNIHFMRQSE MGRR
//
