ID   A0A2K6T650_SAIBB        Unreviewed;       673 AA.
AC   A0A2K6T650;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=RAS guanyl releasing protein 4 {ECO:0000313|Ensembl:ENSSBOP00000015110.1};
GN   Name=RASGRP4 {ECO:0000313|Ensembl:ENSSBOP00000015110.1};
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000015110.1, ECO:0000313|Proteomes:UP000233220};
RN   [1] {ECO:0000313|Ensembl:ENSSBOP00000015110.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RASGRP family.
CC       {ECO:0000256|ARBA:ARBA00009566}.
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DR   RefSeq; XP_003937492.1; XM_003937443.2.
DR   AlphaFoldDB; A0A2K6T650; -.
DR   STRING; 39432.ENSSBOP00000015110; -.
DR   Ensembl; ENSSBOT00000031908.1; ENSSBOP00000015110.1; ENSSBOG00000024200.1.
DR   GeneID; 101048039; -.
DR   KEGG; sbq:101048039; -.
DR   CTD; 115727; -.
DR   GeneTree; ENSGT00940000159883; -.
DR   OrthoDB; 4260488at2759; -.
DR   Proteomes; UP000233220; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR   GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Ensembl.
DR   GO; GO:0009991; P:response to extracellular stimulus; IEA:Ensembl.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd20863; C1_RASGRP4; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR020454; DAG/PE-bd.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF157; RAS GUANYL-RELEASING PROTEIN 4; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   PRINTS; PR00008; DAGPEDOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          49..175
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          201..432
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          466..501
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          540..590
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          593..619
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          638..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   673 AA;  74570 MW;  010DE7363EE30FBC CRC64;
     MNRKDSKRKS HQECTGKTGG RGRPRQARRH KTCPSPREIS KVMASMNLGL LSGGGCSEDE
     LLEKCIQSFD SAGSLRHGDH VLNMVLAMHS WVLPSANLAA RLLTSYQKAT GDAQELRRLQ
     ICHLVRYWLT QHPEVMHQDP QLEEVMGRFW ATVAQEGNSA QRSLGGSSNL LSPGGPGPPP
     PMNSPGLGKK RKVSLLFDHL ETGELAQHLT YLEFRSFQAI TPQDLRSYVL QGSVRGCPAL
     EGSVGLSNSV SRWVQVMVLS RPGPAQRAQV LDKFIHVAQR LHQLQNFNTL MAVTGGLCHS
     AISRLKDSHA HLSPDSTKAL LELTELLASH NNYARYRRTW AGCTGFRLPV LGVHLKDLVS
     LHEAQPDRLP DGRLHLSKLN SLYLRLQELA ALQGQRPPCS ANEDLLHLLT LSLDLFYTED
     EIYELSYARE PRCPKSLPPS PFKAPLVMEW APGVTPKPDR VTLGRHVEQL VESVFKNYDP
     EGRGTISQED FERLSGNFPF ACHGLHPPPR QGRGSFSREE LTGYLLRASA ICSKLGLAFL
     HTFHEVTFRK PTFCDSCSGF LWGVTKQGYR CRECGLCCHK HCRDQVKVEC KKRPGAKGDA
     GPPGAPVPPT PAPHASCGSE ENLSYTLSLE PETGCQLRHA WTQTESPHPT WEPETVPCPV
     MDPPSTPSSK RDS
//