ID A0A2K6T6W7_SAIBB Unreviewed; 1029 AA.
AC A0A2K6T6W7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=RAS p21 protein activator 1 {ECO:0000313|Ensembl:ENSSBOP00000015384.1};
GN Name=RASA1 {ECO:0000313|Ensembl:ENSSBOP00000015384.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000015384.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000015384.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6T6W7; -.
DR Ensembl; ENSSBOT00000032184.1; ENSSBOP00000015384.1; ENSSBOG00000024025.1.
DR GeneTree; ENSGT00940000155846; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd05391; RasGAP_p120GAP; 1.
DR CDD; cd10354; SH2_Cterm_RasGAP; 1.
DR CDD; cd10353; SH2_Nterm_RasGAP; 1.
DR CDD; cd11788; SH3_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR035842; RasGAP_C_SH2.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035841; RasGAP_N_SH2.
DR InterPro; IPR035652; RasGAP_SH3.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 176..267
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 274..336
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 333..423
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 456..559
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 559..672
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 730..924
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1029 AA; 114364 MW; 4DBE90067B6803C1 CRC64;
MMAAEAGSEE GGPVTAGAGG GGAAGGPGPS PGVCRVRIPA ALPVAAAPYP GLVETGVAGT
LGGGAALGSG FLGTGSVAGA SGGAGLTGGG TAAGVAGAAA AAAGPSGDMS LTKLLTSLPA
ETLGPGGVFP PLPPPPHLPP LGAGLGTVDE GDSLDGPEYE EEEVAIPLTA PPTNQWYHGK
LDRTIAEERL RQAGKSGSYL IRESDRRPGS FVLSFLSQMN VVNHFRIIAM CGDYYIGGRR
FSSLSDLIGY YSHVSCLLKG EKLLYPVAPP EPVEDRRRVR AILPYTKVPD TDEISFLKGD
MFIVHNELED GWMWVTNLRT DEQGLIVEDL VEEVVSFISK QEAYNLLMTV GQVCSFLVRP
SDNTPGDYSL YFRTSENIQR FKICPTPNNQ FMMGGRYYNS IGDIIDHYRK EQIVEGYYLK
EPVPMQDQEQ VLNDTVDGKE IYNTIRRKTK DAFYKNIVKK GYLLKKGKGK RWKNLYFILE
GSDAQLIYFE SEKRATKPKG LIDLSVCSVY VVHDSLFDRP NCFQIVVQHF SEEHYIFYFA
GETPEQAEDW MKALQAFCSL RKSSPGTSNK RLRQVSSLVL HIEEAHKLPV KHFTNPYCNI
YLNSVQVAKT HAREGQNPVW SEEFVFDDLP PDINRFEIIL SNKTKKSKDP DILFMRCQLS
RLQKGHATDE WFLLSSHIPL KGIEPGSLRV RARYSMEKIM PEEEYSEFKE LILQKELHVV
YALSHVCGQD RTLLASILLR IFLHEKLESL LLCTLNDREI SMEDEATTLF RATTLASTLM
EQYMKATATQ FVHHALKDSI LKIMESKQSC ELSPSKLEKN EDVNTNLAHL LNILSELVEK
IFMASEILPP TLRYIYGCLQ KSVQHKWPTN TTMRTRVVSG FVFLRLICPA ILNPRMFNII
SDSPSPIAAR TLTLVAKSVQ NLANLVEFGA KEPYMEGVNP FIKSNKHRMI MFLDELGNVP
ELPDTTEHPR TDLSRDLAAL HEICVAHSDE LRTLSNERGA QQHVLKKLLA ITELLQQKQH
QYTKTNDVR
//
