ID A0A2K6T7C8_SAIBB Unreviewed; 619 AA.
AC A0A2K6T7C8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Rho guanine nucleotide exchange factor 25 {ECO:0000313|Ensembl:ENSSBOP00000015546.1};
GN Name=ARHGEF25 {ECO:0000313|Ensembl:ENSSBOP00000015546.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000015546.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000015546.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_003926530.1; XM_003926481.2.
DR AlphaFoldDB; A0A2K6T7C8; -.
DR STRING; 39432.ENSSBOP00000015546; -.
DR Ensembl; ENSSBOT00000032348.1; ENSSBOP00000015546.1; ENSSBOG00000024503.1.
DR GeneID; 101035879; -.
DR CTD; 115557; -.
DR GeneTree; ENSGT00940000160422; -.
DR OrthoDB; 2906033at2759; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13241; PH2_Kalirin_Trio_p63RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR22826:SF117; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 199..375
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 21..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 619 AA; 68028 MW; F89A4A5E9C731BAE CRC64;
MKPPDRPAPG RTDRILGVMG GMLRACALPG QEGPPRRSPL GSGGTEPESE RTEGDHRRDR
EHEVLPWALQ PESYSIAGSE GSISASAASG LAAPSGPSSG PSSGPCSPGP PGPVSGLRKW
LDHSKHCLSV ETEADSGQPG PYENWMLEPA LATGEELPEL TLLTTLLEGP GDKTQPPEEE
TLSQAPESEE EQKKKALERS MYVLSELVET EKMYVDDLGQ IVEGYMATMA AQGVPESLRG
RDRIVFGNVQ QIYEWHRDYF LQELRRCLKD PDWLAQLFIK HERRLHMYVV YCQNKPKSEH
VVSEFGDSYF EELRQQLGHR LQLNDLLIKP VQRIMKYQLL LKDFLKYYSR AGMDTAELEQ
AVEVMCFVPK RCNDMMTLGR LRGFEGKLTA QGKLLGQDTF WVTEPEAGGL LSARGRERRV
FLFEQIVIFS EALGGGMRGG TQPGYVYKSS IKVSCLGLEG NLQGDPCRFA LTSRGPEGGI
QRYILQAADP AVSQAWIKHV AQILESQRDF LNALQSPIEY QRRESQTNSL GRPGGLGVGS
PGRIRLGGRA QGSAHTPING SLPSLLLSPK GEVAKAPLPL DTQALGDIRQ APHDSPPVPP
TPNTPPCQAR LAKLDEDEL
//
