ID A0A2K6T7P0_SAIBB Unreviewed; 771 AA.
AC A0A2K6T7P0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Vav guanine nucleotide exchange factor 2 {ECO:0000313|Ensembl:ENSSBOP00000015659.1};
GN Name=VAV2 {ECO:0000313|Ensembl:ENSSBOP00000015659.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000015659.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000015659.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6T7P0; -.
DR Ensembl; ENSSBOT00000032460.1; ENSSBOP00000015659.1; ENSSBOG00000024511.1.
DR GeneTree; ENSGT00940000159718; -.
DR OMA; MHRDRTD; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd20868; C1_VAV2; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd10406; SH2_Vav2; 1.
DR CDD; cd11980; SH3_VAV2_1; 1.
DR CDD; cd11977; SH3_VAV2_2; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035880; VAV2_SH2.
DR InterPro; IPR035733; VAV2_SH3_1.
DR InterPro; IPR035732; VAV2_SH3_2.
DR PANTHER; PTHR45818:SF4; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2; 1.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07653; SH3_2; 2.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 125..303
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 332..434
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 445..494
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 508..574
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 595..689
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 709..770
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT COILED 217..244
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 771 AA; 89191 MW; 484A54555B79A9DF CRC64;
FLCLKNIRTF LKVCHDKFGL RNSELFDPFD LFDVRDFGKV ISAVSRLSLH SVAQNKGIRP
FPSEETTEND DDVYRSLEEL ADEHDLGEDI YDCVPCEDGG DDIYEDIIKV EVQQPMKMGM
TEDDKRNCCL LEIQETEAKY YRTLEDIEKN YMSPLRLVLS PADMAAVFIN LEDLIKVHHS
FLRAIDVSMM VGGSTLAKVF LDFKERLLIY GEYCSHMEHA QNTLNQLLAN REDFRQKVEE
CTLKVQDGKF KLQDLLVVPM QRVLKYHLLL KELLSHSAER PERQQLKEAL EAMQDLAMYI
NEVKRDKETL RKISEFQSSI ENLQVKLEEF GRPKIDGELK VRSIVNHTKQ DRYLFLFDKV
VIVCKRKGYS YELKEIIELL FHKMTDDPMN NKDVKKWSYG FYLIHLQGKQ GFQFFCKTED
MKRKWMEQFE MAMSNIKPDK ANANHHSFQM YTFDKTTNCK ACKMFLRGTF YQGYLCTKCG
VGAHKECLEV MPPCKITSPA DLDASGAGPG PKMVAMQNYH GNPAPPGKPV LTFQTGDVLE
LLRGDPESPW WEGRLVQTRK SGYFPSSSVK PCPVDGRPPI SRPPSREIDY TAYPWFAGNM
ERQQTDNLLK SHASGTYLIR ERPAEAERFA ISIKFNDEVK HIKVVEKDNW IHITEAKKFD
SLLELVEYYQ CHSLKESFKQ LDTTLKYPYK SRERSASRAS SRAPVFTPRV IGTAVARYNF
AARDMRELSL REGDVVRIYS RIGGDQGWWK GETNGRIGWF PSTYVEEEGI Q
//
