ID A0A2K6TAP4_SAIBB Unreviewed; 1077 AA.
AC A0A2K6TAP4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=SEC24 homolog A, COPII coat complex component {ECO:0000313|Ensembl:ENSSBOP00000016711.1};
GN Name=SEC24A {ECO:0000313|Ensembl:ENSSBOP00000016711.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000016711.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000016711.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR AlphaFoldDB; A0A2K6TAP4; -.
DR STRING; 39432.ENSSBOP00000016711; -.
DR Ensembl; ENSSBOT00000033517.1; ENSSBOP00000016711.1; ENSSBOG00000024973.1.
DR GeneTree; ENSGT00950000182924; -.
DR OMA; AVECSKQ; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR PANTHER; PTHR13803:SF1; PROTEIN TRANSPORT PROTEIN SEC24A; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 2.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 427..463
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 500..738
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 743..814
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 834..923
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 949..1023
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..225
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1077 AA; 118142 MW; A79F2CE432CF8F88 CRC64;
MSQPGIPASG GAPASLQAQN GAASTSGSPY ANGPVQNALL SSQESVNQGY SFQLPGSYPH
LIPAKTLNPV SGQSNHGSSQ GSGQTFNRPP MASNPMTPLL HSDPAPRLPL PASQNPSSTP
LPSGSFLPGA NLPPPLNWQY NYPSTGSQTN HCPRASPQPT VSGNTSLTTN HQYVSSGYPS
PQNNFIKSGS SVPPLVNPPL PTILQPGDPH GPPPAGGPPP INALPPQKSS YRHVPQPSFN
SSVNQEGITS NTNNGSMVVH SSYDEIEGGG FLATPQLTIK NPKMSRSVGY SYPSLLPGYQ
NTPPGATGMP PSSLNYSSGP QAFTQTPLGA NHLTTSMSGL SLHPEGLRVV NLLQERNMLP
STPLQPPVPN LHEDIQKLNC NPELFRCTLT SIPQTQALLN KAKLPLGLLL HPFKDLVQLP
VVTSSTIVRC RSCRTYINPF VSFLDQRRWK CNLCYRVNDV PEEFLYNPLT RVYGEPHRRP
EVQNATIEFM APSEYMLRPP QPPVYLFVFD VSHNAVETGY LNSVCQSLLD NLDLLPGNTR
TKIGFITFDS TIHFYSLQEG LSQPQMLIVS DIEDVFIPMP ENLLVNLNES KELVQDLLKT
LPQMFTKTLE TQSALGPALQ AAFKLMSPTG GRMSVFQTQL PTLGVGALKP REEPNHRSSA
KDIHLTPSTD FYKKLALDCS GQQVAVDLFL LSGQYSDLAS LGCISRYSAG SVYYYPSYHH
QHNPVQVQKL QKELQRYLTR KIGFEAVMRI RCTKGLSIHT FHGNFFVRST DLLSLPNVNP
DAGYAVQMSV EESLNDTQLV SFQSALLYTS SKGKLFVILP PWPPKVLGAE IAGATVDRSM
TASLSDARDA LVNAVIDSLS AYRSSVLSNQ QPGLMVPFSL RLFPLFVLAL LKQKSFQTGT
NARLDERIFA MCQVKNQPLV YLMLTTHPNL YRVDNLSDEG ALNINDRTIP QPPILQLSVE
KLSRDGAFLM DAGSVLMLWV GKNCAQSFLS QVLGVQNYAS VPQPMTDLPE LDTPESARII
TFISWLREQR PFFPILYVIR DESPMKANFL QNMIEDRTES ALSYYEFLLH IQQQVNK
//
