ID A0A2K6TBP0_SAIBB Unreviewed; 1402 AA.
AC A0A2K6TBP0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=NLR family pyrin domain containing 1 {ECO:0000313|Ensembl:ENSSBOP00000017063.1};
GN Name=NLRP1 {ECO:0000313|Ensembl:ENSSBOP00000017063.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000017063.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000017063.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Inflammasome
CC {ECO:0000256|ARBA:ARBA00004110}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR Ensembl; ENSSBOT00000033870.1; ENSSBOP00000017063.1; ENSSBOG00000025041.1.
DR GeneTree; ENSGT00940000162176; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 6.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 295..604
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 1052..1293
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1309..1392
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 161..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1402 AA; 157711 MW; D21D2CD3A5A0BF42 CRC64;
MAGGAWGRLA CYLELLKEED LKKFQLLLTN KVHSRGSLGE SPAQPEKMSG MQVASHLVAQ
YGEQQAWDLA IHTWEQMGLR SLCAQAQEEA GHSSSFPYSL SEPSLGSPNR PTSTAVLRSW
IPELQGCTQG SERSVLRHLP DMSGHRWREI TSSLLYQAPL SSPDYGSPSH ESPNAPTSTA
ELGSWESPLH PSPVPREQEA PGTQWPLDEM LGNCYTGIRE RDQNLWRESP CSTWSWKNED
LNQKFTQLLL LQRPHPRSHE CLVRGRLLHN VEEDQGHLIE IGDLFGPGLD TQEPRIVILQ
GAAGIGKSTL ARWVREAWGR GQLYRDCFQH VFYFSCRELA QSKLLSLAEL IGKDWTATQA
PIRQILSSPE QLLFILDGVD EPKWVLKEQS PELCLHWSQP QPADALLGSL LGRSILPKAS
FLITARTTAL QSLIPSLEQA HWVEVLGFSE SSRKEYFYKY FTDKRQANRA FRLVKSNKEL
WALCLVPWVS WLACTCLMQQ MKQKEELTLT SKTTTTLCLH YFSQALRAQP LGSQLLGFCS
LAAEGIWQRK TLFSPDDLKK HGLDGAIISS LLKMGILQEH PIPLSYSFIH LCFQEFFAAM
SCALEDKKGR SEHSNHIVGL GKLLEAYGTH DLFRAPTTRF LLGLLSKRGT REMENIFDCQ
LSQERKRRLL QCAQFLQPSL QSHSLEFLHC LYETQGKSFL TQMMAHFQEV CMCVETDMEL
LVCTFCIKFC HDVKKLQLIE GRQHGPAWSL DRVVLFRWVP ATDAYWQILF SVLKITGSLK
ELDLSGNLLS LSAVQSLCET LRYPCCLLET LRLAGCGLTA EGCKNLASGL RTSQTLTEVE
LSFNALTDAG AKHLCRGLRQ PSCKLQQLQL VSCGLTSGCC RALASVLSAS PSLKELDLQQ
NDLGDVGVQL LCKGLRHPTC KLTRLGLDQT TLSDETRQEL RALEHEKSQL LLSYTRKPTV
MIPNEGLDTG EMSNSTSSLK RRRLRSETVS SYVAQADLEH LDWSNPPAKA FHSAGMTKKS
IPRIAQQELA CLPSPASHED LHMKPLGTDD DFWGPTGPVA TEVVDKERSL YRVHFPVAGT
YRWPNMGLCF VVREAVTTEI EFCVWDKLLG EINQQHSWMV AGPLLDIKAE PGAIKAVHLP
HFVALQGGHM DTSLFQVAHF KEEGMLLEKP AKVELHHIVL EDPSFSPMGV LLRVIHNALR
IFPITSMVLL YHRIHPEEVT FHLYLIPSDG SIRKELELCY RSPGEPQLFS EFYVGHLGSG
IRLQMKNKTD ETLVWEALVK PGDLTPATTL VPPALKALPS PLDAPGLLHF VDQYREQLVA
RVTSVEPVLD NLLGHVLSQE QYERVLAENT RPSKMRELFS FSQSWDRSCK DRLYQALKET
HPYLIMELWE KGSKKGLLPL GI
//
