ID A0A2K6TGQ5_SAIBB Unreviewed; 957 AA.
AC A0A2K6TGQ5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Neurofilament medium polypeptide {ECO:0000256|ARBA:ARBA00015894};
DE AltName: Full=160 kDa neurofilament protein {ECO:0000256|ARBA:ARBA00030258};
DE AltName: Full=Neurofilament 3 {ECO:0000256|ARBA:ARBA00033124};
DE AltName: Full=Neurofilament triplet M protein {ECO:0000256|ARBA:ARBA00032778};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000018829.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000018829.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_010346047.1; XM_010347745.1.
DR AlphaFoldDB; A0A2K6TGQ5; -.
DR STRING; 39432.ENSSBOP00000018829; -.
DR Ensembl; ENSSBOT00000035646.1; ENSSBOP00000018829.1; ENSSBOG00000026028.1.
DR GeneID; 101052715; -.
DR KEGG; sbq:101052715; -.
DR CTD; 4741; -.
DR GeneTree; ENSGT00940000161685; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF3; NEUROFILAMENT MEDIUM POLYPEPTIDE; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 207..518
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 225..350
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 402..489
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 98..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..654
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..671
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..688
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 957 AA; 106727 MW; 420263483E42C8F3 CRC64;
MGRRRTTGDK WPGTEKGPGG SGCAPGSKFR GPGSRRPRAR GAGAESPLRR SAAPLPSSPT
GARSPRLLGR RLHWAGPWPG TSAAAINGLR RGRQNAVTAT RPKASKMSYT LDSLGNPSAY
RRVTETRSSF SRVSGSPSSG FRSQSWSRGS PSTVSSSYKR SMLAPRLAYS SAMLSSAESS
LDFSQSSSLL NGGSGPGGDY KLSRSSEKEQ LQGLNDRFAG YIEKVHYLEQ QNKEIEAEIQ
ALRQKQASHA QLGDAYDQEI RELRATLEMV NHEKAQVQLD SDHLEEDIHR LKERFEEEAR
LRDDTEAAIR ALRKDIEEAS LVKVELDKKV QSLQDEVAFL RSNHEEEVAD LLAQIQASHI
TVERKDYLKT DISSALKEIR SQLECHSDQN MHQAEEWFKC RYAKLTEAAE QNKEAIRSAK
EEIAEYRRQL QSKSIELESV RGTKESLERQ LSDIEERHNH DLSSYQDTIQ QLENELRGTK
WEMARHLREY QDLLNVKMAL DIEIAAYRKL LEGEETRFST FAGSITGPLY THRQPSVTIS
SKIQKAKVEA PKLKVQHKFV EEIIEETKVE DEKSEMEDAL AAITEELAIS MKEVKEEEAE
EKEEEPEAEE EEVAAKKSPV KATAPEVKGE EEGEKEAEEG QEEEEEEEDE GAKSDQAEEG
GSEKEGSSEK EEGEQEEGET EAEGEGEEAE AKEEKKVEEK SEEVATKEEL VVDAKVEKPE
KAKSPVPKSP VEEAKSKAEV GKGEQKEEER KEVKEAPKEE KVEKKEEKPK DVPEKKKAES
PVKEEAVEEV VTITKSVKVH LEETKEEGKP QQQEKEKAGG EGRSEKEGID KGSKEARKED
IAVNGEVEGK EGEEQETKEK GSGREEEKGV VTNGLDLSPA DEKKGGDKSE EKVVVTKTVE
KITSEGGDGA TKYITKSVTV TQKVEEHEET FEEKLVSTKK VEKVTSHAIV KEVTQSD
//
