ID   A0A2K6TGX2_SAIBB        Unreviewed;       485 AA.
AC   A0A2K6TGX2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Polynucleotide kinase 3'-phosphatase {ECO:0000313|Ensembl:ENSSBOP00000018899.1};
GN   Name=PNKP {ECO:0000313|Ensembl:ENSSBOP00000018899.1};
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000018899.1, ECO:0000313|Proteomes:UP000233220};
RN   [1] {ECO:0000313|Ensembl:ENSSBOP00000018899.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6TGX2; -.
DR   Ensembl; ENSSBOT00000035716.1; ENSSBOP00000018899.1; ENSSBOG00000026000.1.
DR   GeneTree; ENSGT00940000159302; -.
DR   Proteomes; UP000233220; Unplaced.
DR   GO; GO:0046404; F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR   GO; GO:0046403; F:polynucleotide 3'-phosphatase activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd22736; FHA_PNKP; 1.
DR   Gene3D; 2.60.200.20; -; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR041388; FHA_2.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013954; PNK3P.
DR   InterPro; IPR006550; PNKP.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   NCBIfam; TIGR01663; PNK-3'Pase; 1.
DR   PANTHER; PTHR12083; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE; 1.
DR   PANTHER; PTHR12083:SF9; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE; 1.
DR   Pfam; PF13671; AAA_33; 1.
DR   Pfam; PF17913; FHA_2; 1.
DR   Pfam; PF08645; PNK3P; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT   DOMAIN          11..80
FT                   /note="PNK FHA"
FT                   /evidence="ECO:0000259|Pfam:PF17913"
FT   REGION          108..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   485 AA;  53094 MW;  C9CFFD54431B41F5 CRC64;
     MGEVEAPGRL WLESPPGGAP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRTQ VELVADPETR
     TVAVKQLGVN PSTAGTQELK PGLEGSLGVG DTLYLVNGLH PLTLRWEETR TPEARPDTPP
     GTPPVSQEEK RDPEPLKKRI RKSSPGWENL EKLLVFTAVG VKPQSKVAGF DLDGTLITTR
     SGKVFPTGPS DWRILYPEIP RKLRELEAKG YKVLVATHTG LYRKPVTGMW DHLQEQANEG
     TPIAIADSIF VGDAAGRPAN WAPGRKKKDF SCADRLFALN LGLPFATPEE FFLNWPVAGF
     ELPAFDPRTV ARSGPLCLPE SRALLSSSPE VVVAVGFPGA GKSSFLKEHL VSAGYVHVNR
     DTLGSWQRCV TACEMALKQG KRVAIDNTNP DASSRARYVQ CARAAGVPCR CFLFTATLEQ
     ARHNNRFREM TDSSHAPVSD VVMYGYRKQF EAPTLAEGFA AILEIPFRLS LEPRLERLYC
     QFSEG
//