ID A0A2K6TK52_SAIBB Unreviewed; 749 AA.
AC A0A2K6TK52;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Forkhead box M1 {ECO:0000313|Ensembl:ENSSBOP00000019980.1};
GN Name=FOXM1 {ECO:0000313|Ensembl:ENSSBOP00000019980.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000019980.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000019980.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; A0A2K6TK52; -.
DR STRING; 39432.ENSSBOP00000019980; -.
DR Ensembl; ENSSBOT00000036805.1; ENSSBOP00000019980.1; ENSSBOG00000026585.1.
DR GeneTree; ENSGT00940000158804; -.
DR OMA; APKQEHR; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IEA:Ensembl.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0032873; P:negative regulation of stress-activated MAPK cascade; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:2000781; P:positive regulation of double-strand break repair; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; IEA:Ensembl.
DR CDD; cd20029; FH_FOXM; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047516; FH_FOXM1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR042839; FOXM1.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46878; FORKHEAD BOX PROTEIN M1; 1.
DR PANTHER; PTHR46878:SF1; FORKHEAD BOX PROTEIN M1; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 205..298
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 205..298
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 82842 MW; F0CC478035F08EAD CRC64;
MKTSPRRPLI LKRRRLPLPV QNGPSETSEE EPKRSLAQKE HSQAQASKEV AESSSCKFPA
GIKIINHPTM PNTQVVAIPN NANIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPR
LQPQIQTSCD AKRTEVTMET LGPKPGTTDI NLPRPPGALC GQKQESCGMW SSRQRGEGAQ
PFLSSGKVEE PSRPSTSWQN SVSERPPYSY MAMIQFAINS TERKRMTLKD IYTWIEDHFP
YFKHIAKPGW KNSIRHNLSL HDMFVRETSA NGKVSFWTIH PSANRYLTLD QVFKPLDPGS
PQLPEHLESQ QKRPNPELRR NVTIKTELPL GARRKMKPLL PRVSSYLVPI QFPVNQSLVL
QPSVKVPLPL AASLMSSELA RHSKRIRIAP KVGVFLFSSE ERFWPMKNVL LAEEGIAPLP
SAGPVKEEKL LFGEGLSPLL PVQSIKEEEI QPGEEMPHLV RPIKVESPPL QEWPSPGPSF
KEESSPSWED LSQSPTPRPK KSYSGLRSPT RCVSEMLAIK HRERREMSRS RRKQHLMPPC
VDEPELLFSE GPSTSRWAAE LPFPADSSEP TSQLSYPQEE GGPFKTPIKE TMPISSTPSK
SVLPRTPESW RLTPPARVGG LNFSPVQTPQ GAFGPLPDPL GLIDLSTTPL KSVPTFESPQ
RLLSSEPLDL ASDPFGNSSP SDMEVPKPGS PEPQVSGLAA NRSLTEGLVL DTMNDSLSKI
LLDISFPGLE EDPLGPDNIN WSQLITELQ
//
