ID A0A2K6TKV7_SAIBB Unreviewed; 1931 AA.
AC A0A2K6TKV7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Dedicator of cytokinesis 3 {ECO:0000313|Ensembl:ENSSBOP00000020284.1};
GN Name=DOCK3 {ECO:0000313|Ensembl:ENSSBOP00000020284.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000020284.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000020284.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR Ensembl; ENSSBOT00000037116.1; ENSSBOP00000020284.1; ENSSBOG00000026306.1.
DR GeneTree; ENSGT00940000155514; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08695; C2_Dock-B; 1.
DR CDD; cd11704; DHR2_DOCK3; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR InterPro; IPR037811; C2_Dock-B.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026800; DHR2_DOCK3.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF4; DEDICATOR OF CYTOKINESIS PROTEIN 3; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 331..509
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1129..1536
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1635..1672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1750..1828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1852..1931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1635..1666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1772..1821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1865..1881
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1882..1906
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1931 AA; 221780 MW; D78EA6A75A535F83 CRC64;
SSRSSFPDGI VCLGFKHKVD LFYKLRHVMN ELIDLRRQLL SGHLTQDQVR EVKRHITVRL
DWGNEHLGLD LVPRKDFEVV DSDQISVSDL YKMHLSSRQS VQQSTSQVDT MRPRHGETCR
MPVPHHFFLS LKSFTYNTIG EDTDVFFSLY DMREGKQISE RFLVRLNKNG GPRNPEKIER
MCALFTDLSS KDMKRDLYIV AHVIRIGRML LNDSKKGPPH LHYRRPYGCA VLSILDVLQS
LTEVKEEKDF VLKVYTCNNE SEWSQIHENI IRKSSAKYSA PSASHGLIIS LQLLRGDMEQ
IRRENPMIFN RGLAITRKLG FPDVIMPGDI RNDLYLTLEK GDFERGGKSV QKNIEVTMYV
LYADGEILKD CISLGSGEPN RSSYHSFVLY HSNSPRWGEI IKLPIPIDRF RGSHLRFEFR
HCSTKDKGEK KLFGFAFSPL MRDDGTTLSD DIHELYVYKC DENSTFNNHA LYLGLPCCKE
DYNGCPNIPS SLIFQRSTKE SFFISTQLSS TKLTQNVDLL ALLKWKAFPD RIMDVLGRLR
HVSGEEIVKF LQDILDTLFV ILDDNTEKYG LLVFQSLVFI INLLRDIKYF HFRPVMDTYI
QKHFAGALAY KELIRCLKWY MDCSAELIRQ DHIQEAMRAL EYLFKFIVQS RILYSRATCG
MEEEQFRSSI QELFQSIRFV LSLDSRNSET LLFTQAALLN SFPTIFDELL QMFTVQEVAE
FVRGTLGSMP STVHIGQSMD VVKLQSIART VDSRLFSFSE SRRILLPVVL HHIHLHLRQQ
KELLICSGIL GSIFSIVKTS SLEADVMEEV EMMVESLLDV LLQTLLTIMS KSHAQEAVRG
QRCPQCTAEI TGEYVSCLLS LLRQMCDTHF QHLLDNFQSK DELKEFLLKI FCVFRNLMKM
SVFPRDWMVM RLLTSNIIVT TVQYLSSALH KNFTETDFDF KVWNSYFSLA VLFINQPSLQ
LEIITSAKRK KILDKYGDMR VMMAYELFSM WQNLGEHKIH FIPGMIGPFL GVTLVPQPEV
RNIMIPIFHD MMDWEQRKNG NFKQVEAELI DKLDSMVSEG KGDESYRELF SLLLLEKVEQ
ETWRETGISF VTSVTRLMER LLDYRDCMKG EETENKKIGC TVNLMNFYKS EINKEEMYIR
YIHKLCDMHL QAENYTEAAF TLLLYCELLQ WEDRPLREFL HYPSQTEWQR KEGLCRKIIH
YFNKGKSWEF GIPLCRELAC QYESLYDYQS LSWIRKMEAS YYDNIMEQQR LEPEFFRVGF
YGRKFPFFLR NKEYVCRGHD YERLEAFQQR MLSEFPQAVA MQHPNHPDDA ILQCDAQYLQ
IYAVTPIPDY VDVLQMDRVP DRVKSFYRVN NVRKFRYDRP FHKGPKDKEN EFKSLWIERT
TLTLTHSLPG ISRWFEVERR ELVEVSPLEN AIQVVENKNQ ELRSLISQYQ HKQVHGNINL
LSMCLNGVID AAVNGGIARY QEAFFDKDYI NKHPGDAEKI TQLKELMQEQ VHVLGVGLAV
HEKFVHPEMR PLHKKLIDQF QMMRASLYHE FPGLDKLSPA CSGTSTPRGN VLASHGPMSP
ESIKMTHRHS PMNLMGTGRH SSSSLSSHAS SEAGNMVMLG DGSMGDAPED LYHHMQLAYP
NPRYQGSITN VSVLSSSQAS PSSSSLSSTH SAPSQMITSA PSSARGSPSL PDKYRHAREM
MLLLPTYRDR PSSAMYPAAI LENGQPPNFQ RALFQQVVGA CKPCSDPNLS VAEKGHYSLH
FDAFHHPLGD TPPALPARTL RKSPLHPIPA SPTSPQSGLD GSNSTLSGSA SSGVSSLSES
NFGHSSEAPP RTDTMDSMPS QAWNADEDLE PPYLPVHYSL SESAVLDSIK AQPCRSHSAP
GCVIPQDPMD PPALPPKPYH PRLPALEHDE GVLLREETER PRGLHRKASL PPGSTKEEQA
RMAWEHGRGE Q
//
