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Database: UniProt
Entry: A0A2K6TLI4_SAIBB
LinkDB: A0A2K6TLI4_SAIBB
Original site: A0A2K6TLI4_SAIBB 
ID   A0A2K6TLI4_SAIBB        Unreviewed;       525 AA.
AC   A0A2K6TLI4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=NADPH oxidase 1 {ECO:0000313|Ensembl:ENSSBOP00000020446.1};
GN   Name=NOX1 {ECO:0000313|Ensembl:ENSSBOP00000020446.1};
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000020446.1, ECO:0000313|Proteomes:UP000233220};
RN   [1] {ECO:0000313|Ensembl:ENSSBOP00000020446.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A2K6TLI4; -.
DR   STRING; 39432.ENSSBOP00000020446; -.
DR   Ensembl; ENSSBOT00000037278.1; ENSSBOP00000020446.1; ENSSBOG00000026785.1.
DR   GeneTree; ENSGT00940000161632; -.
DR   OMA; CMEVGQY; -.
DR   Proteomes; UP000233220; Unplaced.
DR   GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR   GO; GO:0043020; C:NADPH oxidase complex; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0016175; F:superoxide-generating NAD(P)H oxidase activity; IEA:Ensembl.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR   GO; GO:0071455; P:cellular response to hyperoxia; IEA:Ensembl.
DR   GO; GO:1990451; P:cellular stress response to acidic pH; IEA:Ensembl.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR   GO; GO:0042743; P:hydrogen peroxide metabolic process; IEA:Ensembl.
DR   GO; GO:0051454; P:intracellular pH elevation; IEA:Ensembl.
DR   GO; GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IEA:Ensembl.
DR   GO; GO:0007254; P:JNK cascade; IEA:Ensembl.
DR   GO; GO:0072592; P:oxygen metabolic process; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0045726; P:positive regulation of integrin biosynthetic process; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:1902177; P:positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR   GO; GO:0003081; P:regulation of systemic arterial blood pressure by renin-angiotensin; IEA:Ensembl.
DR   GO; GO:0042554; P:superoxide anion generation; IEA:Ensembl.
DR   CDD; cd06186; NOX_Duox_like_FAD_NADP; 1.
DR   Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 1.
DR   InterPro; IPR000778; Cyt_b245_heavy_chain.
DR   InterPro; IPR013112; FAD-bd_8.
DR   InterPro; IPR017927; FAD-bd_FR_type.
DR   InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR   InterPro; IPR013121; Fe_red_NAD-bd_6.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR   PANTHER; PTHR11972; NADPH OXIDASE; 1.
DR   PANTHER; PTHR11972:SF71; NADPH OXIDASE 1; 1.
DR   Pfam; PF08022; FAD_binding_8; 1.
DR   Pfam; PF01794; Ferric_reduct; 1.
DR   Pfam; PF08030; NAD_binding_6; 1.
DR   PRINTS; PR00466; GP91PHOX.
DR   SFLD; SFLDG01169; NADPH_oxidase_subgroup_(NOX); 1.
DR   SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR   SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR   PROSITE; PS51384; FAD_FR; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        45..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        103..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        167..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        203..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          236..360
FT                   /note="FAD-binding FR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51384"
SQ   SEQUENCE   525 AA;  60207 MW;  E6095CDD5B46B9BC CRC64;
     MGNWVVNHWF SVLFLAVWLG LNVFLFVDAF LKYEKADKYY YTRKILGSTL ACARASALCL
     NFNSMLILLP VCRNLLSFVR GTCSFCSRTL RKQLDHNLTF HKLVAYMICL HTAIHIIAHL
     FNFDYYSRSR QATDGSLASI LSSLSHDEKK GDSWLNPIQS PNMTVEYVTF TSIAGLTGVI
     MTIALILMVA SATEFIRRSY FEVFWYTHHV FIFYILGLGI HGIGGIVRGQ TEKSMNESHP
     CKCAESFEMW DDRDSHCRRP EFEGHPPEVV MHPSKVVELQ MNKRGFSMEV GQYIFVNCPS
     ISLLEWHPFT LTSAPEEDFF SIHIRAAGDW TENLIRAFEQ QYLTIPRIEV DGPFGTASED
     VFQYEVAVLV GAGIGVTPFA SILKSIWYKF QCADHNLKTK KIYFYWICRE TGAFSWFNDL
     LTSLEQEMEE LGKVGFLNYR LFLTGWDSNI DKATDILTGL KQKTSFGRPM WDNEFSKIAT
     SHPKSVVGVF LCGPQALAKS LRKCCHRYSS LDPRKVQFYF NKENF
//
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