ID A0A2K6TLW2_SAIBB Unreviewed; 3396 AA.
AC A0A2K6TLW2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=PKHD1 ciliary IPT domain containing fibrocystin/polyductin {ECO:0000313|Ensembl:ENSSBOP00000020618.1};
GN Name=PKHD1 {ECO:0000313|Ensembl:ENSSBOP00000020618.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000020618.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000020618.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSSBOT00000037451.1; ENSSBOP00000020618.1; ENSSBOG00000026830.1.
DR GeneTree; ENSGT00940000160697; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00603; IPT_PCSR; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 2.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR46769:SF1; FIBROCYSTIN; 1.
DR PANTHER; PTHR46769; POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1; 1.
DR Pfam; PF10162; G8; 2.
DR Pfam; PF01833; TIG; 8.
DR SMART; SM01225; G8; 2.
DR SMART; SM00429; IPT; 5.
DR SMART; SM00710; PbH1; 8.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF81296; E set domains; 6.
DR SUPFAM; SSF51126; Pectin lyase-like; 2.
DR PROSITE; PS51484; G8; 2.
DR PROSITE; PS51820; PA14; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..3396
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014442691"
FT DOMAIN 322..485
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT DOMAIN 1932..2053
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT DOMAIN 2747..2873
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
SQ SEQUENCE 3396 AA; 371490 MW; 6121FA6268EB6ACA CRC64;
MTAWLISLMS IEVLLLAVPH LTLHIEPEEG SLAGGTWITV IFDGLESSVL YPNNGSQLEI
YLVNVSMVVP ALPSIPCDVF PVFLDFPVVT CRTRSLQSEA HEGLYCLEAY FGGQLISSPS
PGLRDSCIFK FSKAQTPIVH QVYPSSGVPG KLIHVYGWII TGRLETFDFD AEYIDSPVIL
EAQGDKWVTP CSLVNRQTGN CYPIQEDHGL GTLQCHVEGD YIGSQNVSFS VFNRGKSMVH
KKAWLISAKQ DLFLYQTHSE ILSVFPETGS LGGRTDITIT GDFFDSSAQV TIAGIPCDIR
HVSSRKIECT TRAPGKNARL TSPQPGNRGL LFEVGDAVEG LELTEATPGY RWQIVPNASS
PFGFWSKEGQ PFRARLSGFF VAPETNNYTF WIQADSQASL HFSWSEEPRT KMKVASISVG
TTNWFDSWEQ NRDEGTWQQK TPKLELLGGA RYYLEAEHHG IAPSTGMRIG VQIHNTWLNP
DVVTTYLREK HQIRVRAQRF PEVQVLNVSG RGNFFLTWDN VSSQPIPANA TAHLIQTTIE
ELLAVKCKLE PLSANILLRL GFERGPEVSS SDGDLTSGTE PFCGRFSLRQ PRHLVLAPSA
AQKGYRLDQY TQLCLAYKGH TNKILKMTVS FTIGFQNMVK NTTCDWSLMR TSPKSWQFRC
TDLWETCVRC SGDLQPAPAN SPVLVHQIDL LPLAQETGLF YVDEIIIADT NLTVSQADSG
TARPGGNLVE SVSVAGSPPV YSVTSWLAGC GTELPLITAR SVLTEGTEQG SGPVLVTTQR
RQRTSPPLGG HFRIQLPNTV ISDVPVHISA HHLQQLLQNN ADDFTSRYLN ASDFTVKEDV
NTCYEHVWTL SWSTQIGDLP NFIRVSDENL TGVNPAAATR VVYDGGVFLG PIFGDMLATA
NQHSQVVVRV NDVPAYCSGS CSFQYLQGST PWVHSVWYSI DGDINLMVYI TGTGFSGDSQ
FLEVTVNKTN CKVIFSNQTN VVCQTDLLPV GVHRILMLVR PSGLAIIATG EDLFLNVEPR
LDAVEPSRAA ETGGLWATIR GSSLEGVSLV LFGSYSCAIN VTISNSSRIQ CKVPPRGKDG
HIVNVTVIRG DYSAVLPGAF TYVSSLNPVI VTLSRNTSNI AGGETLVIGV ALLVNCTDLD
VEVHIQDALA PVHTQAAWGL EVALPPLPAG LHGISVSING VSIRSQGVDL HIQYITEVFS
IEPCCGSLLG GTILSISGIG FSRDPALVWV LVGNRSCDIV NLMEASIWCV TPPAPQMPHA
GTSTVPAAVE IWAGNRSFTR GPSPSLVGNS FTFTYEAAAT PLVTALQAEI TNSSLRLRVG
GSNLSNSVIL LGRLNCDVDT ESFQSNASLS GCSIPLHSLE ADIYPLQIRH KQMGFANRSA
VPQPFAVMPL IMAIVPSQGS VCGGTILTVR GLLFNSRRRS VRVDLSGPFT CVILHLEDRT
ILCQVSLAGD PLLGASFTMN VTVLVNGLTS ECQGNCTFFM QEEASPVMNA LTTNTSGSLT
TVLMRGQRLG TTADELMVFV DDQLPCNVTF LNASHVACQM RDLAPGLHYL SVFYARNGYA
CTGNVSRHFY ITPQVFHYFP KNFSIHGGGL LTIEGTGLRG QNTTSVYIDQ QACLMMNISA
ELIQCIVPTG NGSVALGIEV DGLLYHIGVV GYSNAFTPEL LSISQRDDIL TFTVAQISGA
ANIDIFIGMS SCMGVSGNHS VLQCVVPSLP AGEYHVRAYD YIRGWASSVQ VFTSRVIITA
VTKNFGCLGG RLVHVFGAGF SPGNVSAAVC GAPCRVLANA TVSAFSCLVP PLDVSLTFLC
DVKHEEDSCE AARHTYVQCD LTVAVGTEQL LESWPYLYIC EESSQCLFVP DHWAESMFPS
FLGLFISPKV ERDEVLIYNS SCNITMETEA EMECETPNQP ITVKITEIRK RWGQNTQGNS
PFQFCRRWSR THSWFPERLP QDGDNVTVEN GQLLLLDTNT SILNLLHVKG GKLIFLAPGP
IELRAHAILV SDGGELRIGS KDKPFQGRAQ ITLYGSSHST PFFPYGVKFL AVRNGTLSLH
GLLPKVIVTH LRATAHARDT VLALEDAVDW HPGDEVVIIS GTSVEGARPM EEIVTVETVQ
DTDLYLKSPL RYSHNFTENW VAGEHHILKA TVALLSRSIT IQGNLTNERE KLLVACQEAN
APEGHLQHCL YSMSEKTLGS RDMGARVIVQ SFPEEPSGVQ LRGVQFRVLG QAFRKHLSSL
ILVGAMRESF VQGCTVWNSF SRGLSMCRTL GLKVDSNVFY NILGHALLVG TCMEMRYISW
EAIRGRKDDW SGHGNIIRNN IIIRVSGAEG LSNPEMLTPS GIYIRSPTNV IEGNRVCAAG
YGYFFHLVTS QTSRAPLLSF TQNIAHSCTR CGLFVYPKFQ PPWNNVTGTT LFQNFTVWES
AGGAQIFRSS NLHLKNFQVY SCRDFGIDIL ESDANTSVTD SLLLGHFAHK GSLCMSSGIK
TPKRWELMVS NTIFVNFDLI NCVAIRTCSG CSRGQGGFTV KTSQLKFTNS SNLVAFPFPH
AAILEDLDGS LSGKNRSHIL ASMETLSASC LVNASFGRVV HGSACGGGVL FHRMSIGLAN
APEVSCDLTM TDSRNKTTTV NYVRDTLSNP YGWMALLLDQ ETYSLHFENL WINRSLQYSA
TFDNFAPGNY LWLVHTDLPP YPDILLKCGS RVGLSLPFLP SPAQNQGCDW FFNSQLRQLT
YLVSGEGQVQ VILQVKEGMP PTISASTSAP DSALKWSLPE TWQGVEEGWG GHNNTIPGPG
DDVLILPNRT VLVDTDLPFF KGLYVLGTLD FPVDRSNVLS VACMVIAGGE LKVGTLENPL
EKEQKLLILL RASEGVFCDR LNGMHVEPGT IGVYGKVQLY SAYPKNSWTH LGADIASGNE
RLILEDAVDW RPQDKIVLSS SSYEPHEAEV LTVKEVKGHY VRIHERLKHR HIGSVHVMED
GRHIHLAAEV GLLTRNIQIQ PDVSCRGRLL VGSFRKSSRE EFSGILQLLN VEIQNFGSSL
YSSVEFSNVS TGSWIISSTL HQSCGGGIHA AASHGVRLND NIVFSTAGHG IDLEGQAYSL
TNNLVVLMTQ PAWSNIWVAG IKVNQVKDIN LHGNVVAGSE RLGFHIRGYK CSSCEVLGSD
NVAHSSLHGL HLYKESGLDN CTRISGFLAF KNFDYGAMLH VENNVEIENI TLVDNTIGLL
AVVYVFSAPQ NSIKNVQIVL KNSVIVATSS SFDCLQDKVK PYSANLTSSD RAPSNPRGGR
IGVLWPVFTS EPNQWPQEPW HKVRNDRSIS GIMKLQDVTF SSFVKSCYSD DLDVCILPNA
ENTGIMHPIT AERTRMLKMK DKNKFYFSPS QPRKDLGKVV CPELDCATPR KYLFKDLDGR
ALGLPPPVSV FPKTEAEWTA SFFNAVTTEQ ALKISE
//
