ID   A0A2K6TQS7_SAIBB        Unreviewed;       726 AA.
AC   A0A2K6TQS7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Sodium voltage-gated channel alpha subunit 2 {ECO:0000313|Ensembl:ENSSBOP00000022018.1};
GN   Name=SCN2A {ECO:0000313|Ensembl:ENSSBOP00000022018.1};
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000022018.1, ECO:0000313|Proteomes:UP000233220};
RN   [1] {ECO:0000313|Ensembl:ENSSBOP00000022018.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6TQS7; -.
DR   Ensembl; ENSSBOT00000038864.1; ENSSBOP00000022018.1; ENSSBOG00000026760.1.
DR   GeneTree; ENSGT00940000154224; -.
DR   Proteomes; UP000233220; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:UniProt.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR043203; VGCC_Ca_Na.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF278; SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        397..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          145..430
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          554..705
FT                   /note="Voltage-gated Na+ ion channel cytoplasmic"
FT                   /evidence="ECO:0000259|Pfam:PF11933"
FT   REGION          28..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          490..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          584..606
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          661..681
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          421..466
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        28..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        506..525
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   726 AA;  81900 MW;  C1DCFB94CC95E451 CRC64;
     MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK
     SLPFIYGDIP PEMVSVPLED LDPYYINKKT FIVLNKGKAI SRFSATPALY ILTPFNPIRK
     LAIKILVHSY PFSNRFLIRL SSLTNNPPDW TKNVEYTFTG IYTFESLIKI LARGFCLEDF
     TFLRDPWNWL DFTVITFAYV TEFVDLGNVS ALRTFRVLRA LKTISVIPGL KTIVGALIQS
     VKKLSDVMIL TVFCLSVFAL IGLQLFMGNL RNKCLQWPPD NSSFEINITS FFNNSLDGNG
     TAFNRTVSMF NWDEYIEDKS HFYFLEGQND ALLCGNSSDA GQCPEGYICV KAGRNPNYGY
     TSFDTFSWAF LSLFRLMTQD FWENLYQLTL RAAGKTYMIF FVLVIFLGSF YLINLILAVV
     AMAYEEQNQA TLEEAEQKEA EFQQMLEQLK KQQEEAQAAA AAASAESRDF SGAGGIGVFS
     ESSSVASKLS SKSEKELKNR RKKKKQKEQS GEEEKNDRVR KSESEDSIRK KGFRFSLEGS
     RLTYEKRFSS PHQSLLSIRG SLFSPRRNSR ASLFSFRGRT KDVGSENDFA DDEHSTFEDN
     DSRRDSLFVP HRHGERRHSN VSQASRASRV LPILPMNGKM HSAVDCNGVV SLVGGPSTLT
     SAGQLLPEGT TTETEIRKRR SSSYHVSMDL LEDPASRQRA MSIASILTNT MEGKSFEDCL
     AFCSLP
//