ID A0A2K6TU58_SAIBB Unreviewed; 1707 AA.
AC A0A2K6TU58;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 3 {ECO:0000313|Ensembl:ENSSBOP00000023205.1};
GN Name=TRPM3 {ECO:0000313|Ensembl:ENSSBOP00000023205.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000023205.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000023205.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_003935677.1; XM_003935628.1.
DR Ensembl; ENSSBOT00000040060.1; ENSSBOP00000023205.1; ENSSBOG00000027739.1.
DR GeneID; 101040056; -.
DR CTD; 80036; -.
DR GeneTree; ENSGT00940000157366; -.
DR OrthoDB; 201873at2759; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF7; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 873..892
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 940..958
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 970..988
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1009..1029
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1087..1112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 153..418
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 880..1121
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1215..1270
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 808..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1585..1604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1634..1707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1218..1276
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1707 AA; 194769 MW; 9F89DFE0C00D9C7D CRC64;
MPEPWGTVYF LGIAQVCSFW FSRWNLEGVM NQADVPRPLN WTIRKLCHAA FLPSVRLLKA
QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT PSISVLQNEK NESRLSRNDI
QSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSF DTKPDLLLHL MTKEWQLELP
KLLISVHGGL QNFELQPKLK QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS
KSRGKICTIG IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT
GKYGAEVKLR RQLEKHISLQ KINTRIGQGV PVVALIVEGG PNVISIVLEY LRDTPPVPVV
VCDGSGRASD ILAFGHKYSE EGGLINESLR DQLLVTIQKT FTYTRTQAQH LFIILMECMK
KKELITVFRM GSEGHQDIDL AILTALLKGA NASAPDQLSL ALAWNRVDIA RSQIFIYGQQ
WPVGSLEQAM LDALVLDRVD FVKLLIENGV SMHRFLTISR LEELYNTRHG PSNTLYHLVR
DVKKGNLPPD YRISLIDIGL VIEYLMGGAY RCNYTRKRFR TLYHNLFGPK RPKALKLLGM
EDDIPLRRGR KTTKKREEEV DIDLDDPEIN HFPFPFHELM VWAVLMKRQK MALFFWQHGE
EAMAKALVAC KLCKAMAHEA SENDMVDDIS QELNHNSRDF GQLAVELLDQ SYKQDEQLAM
KLLTYELKNW SNATCLQLAV AAKHRDFIAH TCSQMLLTDM WMGRLRMRKN SGLKVILGIL
LPPSILSLEF KNKDDMPYMS QAQEIQLQEK EAEEPEKPTK EKDEEDMELT AMLGRNNGES
SRKKDEEEVQ SRHRLIPLGR KIYEFYNAPI VKFWFYTLAY IGYLMLFNYI VLVKMERWPS
TQEWIVISYI FTLGIEKMRE ILMSEPGKLL QKVKVWLQEY WNVTDLIAIL LFSVGMILRL
QDQPFRSDGR VIYCVNIIYW YIRLLDIFGV NKYLGPYVMM IGKMMIDMMY FVIIMLVVLM
SFGVARQAIL FPNEEPSWKL AKNIFYMPYW MIYGEVFADQ IDPPCGQNET REDGKIIQLP
PCKTGAWIVP AIMACYLLVA NILLVNLLIA VFNNTFFEVK SISNQVWKFQ RYQLIMTFHE
RPVLPPPLII FSHMTMIFQH LCCRWRKHES DPDERDYGLK LFITDDELKK VHDFEEQCIE
EYFREKDDRF NSSNDERIRV TSERVENMSM RLEEVNEREH SMKASLQTVD IRLAQLEDLI
GRMATALERL TGLERAESNK IRSRTSSDCT DAAYIVRQSS FNSQEGNTFK LQESIDPAGE
ETMSPTSPTL MPRMRSHSFY SVNMKDKGGI EKLESIFKER SLSLHRATSS HSVAKEPKAP
AAPANTLAIV PDSRRPSSCI DIYVSAMDEL HCDIDPLDNS MNILGLGEPS FSTPVPSTAL
SSSAYATLAP TDRPPSRSID LEDITSMDTR SFSSDYTHLP ECQNPWDSDP PMYHTIERSK
SSRYLATTPF LLEEAPIVKS HSFMFSPSRS YYANFGVPVK TAEYTSITDC IDTRCVNAPQ
AIADRAAFPG GLGDKVEDLS CCHPEREAEL SHPGSDSEEN EAKSRRATIA ISSQEGDNSD
RTLSNNITVP KIERANSYSA EEPSVPYAHT RKSFSISDKL DRQRNTASLR NPFQRSKSSK
PEGRGDSLSM RRLSRTSAFQ SFESKHH
//
