ID A0A2K6TZG1_SAIBB Unreviewed; 1046 AA.
AC A0A2K6TZG1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Unconventional myosin-Ia {ECO:0000256|ARBA:ARBA00039640};
DE AltName: Full=Brush border myosin I {ECO:0000256|ARBA:ARBA00041221};
DE AltName: Full=Myosin I heavy chain {ECO:0000256|ARBA:ARBA00041380};
GN Name=MYO1A {ECO:0000313|Ensembl:ENSSBOP00000025052.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000025052.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000025052.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR AlphaFoldDB; A0A2K6TZG1; -.
DR STRING; 39432.ENSSBOP00000025052; -.
DR Ensembl; ENSSBOT00000041918.1; ENSSBOP00000025052.1; ENSSBOG00000028972.1.
DR GeneTree; ENSGT00940000160660; -.
DR OMA; IKPNEYQ; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005903; C:brush border; IEA:Ensembl.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0031941; C:filamentous actin; IEA:Ensembl.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0044853; C:plasma membrane raft; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030033; P:microvillus assembly; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR GO; GO:0051648; P:vesicle localization; IEA:Ensembl.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF291; UNCONVENTIONAL MYOSIN-IA; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 8..697
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 861..1045
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 574..596
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1025..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 101..108
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1046 AA; 118121 MW; 473E44018636A3BA CRC64;
MPLLEGSVGV EDLVLLESLV EESLLKNLQL RYENKEIYTY IGNVVISVNP YQQLPIYGPE
YIAKYQDYTF YELKPHIYAL ANVAYQSLRD RDRDQCILIT GESGSGKTEA SKLVMSYVAA
VCGKGEQVNS VKEQLLQSNP VLEAFGNAKT IRNNNSSRFG KYMDIEFDFK GSPLGGVITN
YLLEKSRVVK QLKGERNFHI FYQLLAGADA QLLKALKLER DTTGYAYLNQ EASRVDGMDD
ASSFSAVQSA MAVIGFSEEE IRQVLEVTAV VLKLGNVMVA DEFQANGIPA SGICDGREVQ
EIGEMVGLSS EELERALCSR TMETAKEKVV TALNVMQAQY ARDALAKNIY SRLFNWIVNR
INESIKVGIG EKKKVMGVLD IYGFEILEDN SFEQFVINYC NEKLQQVFIE MTLKEEQEEY
KREGIPWTKV DYFDNGIICN LIEHNQRGIL AMLDEECLRP GVVSDSTFLA KLNQLFSNCF
RICHYAGKIR AQAQAEGNTG GTWGKGQVLG QGCGVTYNVT SFIDKNNDLL FRDLSQAMWK
AQHPLIRSLF PEGNPKQASL KRPPTAGAQF KSSVAILMKN LYSKNPNYIR CIKPNEHQQR
GQFSSDLVAT QAQYLGLLEN VRVRRAGYAH RQGYGPFLER YRLLSRSTWP RWNGGDREGV
EKILGELSIS SGELAFGKTK IFIRSPKTLF YLEEQRRLRL QQLATLIQKI YRGWRCRTHY
QLMRKSQILI SSWFRGNMQK KRYGKIKASV LLIQAFVRGW KARKNYRKYF RSEAALTLAD
FIYKSMVQKF LLGLKNNLPS TNVLDKTWPA APYKCFSTAN QELRQLFYRW KCKRFRDQLS
PKQVETLREK LCASELFKGK KASYPQSVPI PFCGDYIGLQ GNPKLQKLKG GEEGPVLMAE
AVKKVNRGNG KTSSRILLLT KGHVILTDTK KSQAKTVIGL DDVAGVSVTS LKDGLFSLHL
SEMSSVGSNG DFLLVSEHVI ELLTRMYRAV LDATQRQLAV TVTEKFSMRF KENSLAVRVV
QGPAGGDNSK LRCKKKGSHS LEVTVQ
//
