ID A0A2K6U1D7_SAIBB Unreviewed; 471 AA.
AC A0A2K6U1D7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Keratin, type II cytoskeletal 8 {ECO:0000256|ARBA:ARBA00039429};
DE AltName: Full=Cytokeratin-8 {ECO:0000256|ARBA:ARBA00042964};
DE AltName: Full=Keratin-8 {ECO:0000256|ARBA:ARBA00042886};
DE AltName: Full=Type-II keratin Kb8 {ECO:0000256|ARBA:ARBA00043133};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000025694.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000025694.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Together with KRT19, helps to link the contractile apparatus
CC to dystrophin at the costameres of striated muscle.
CC {ECO:0000256|ARBA:ARBA00037766}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; A0A2K6U1D7; -.
DR STRING; 39432.ENSSBOP00000025694; -.
DR Ensembl; ENSSBOT00000042563.1; ENSSBOP00000025694.1; ENSSBOG00000029311.1.
DR GeneTree; ENSGT00940000153339; -.
DR OMA; HSNVDAM; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF26; KERATIN, TYPE II CYTOSKELETAL 8; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 93..391
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 97..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 163..227
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 332..369
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 471 AA; 52058 MW; 3BCF458F3314471E CRC64;
MSIRVTLKSY RVSTSGPGAF SSRSFMSGPS ARSNSLSYSR VSSTGFRGGL GAGYAGASGI
GMGGITAVTI NQSLLNPIKL DVDPNIQAVC TQEKEQIKTL NNKFASFIDK VRFLEQQNKM
LETKWNLLQQ QKMARSNMDN MFESSINNLG WQLETLGQEK LKLEAELGNM QGLEEINKRT
EMENEFVLIK KDVDEAYMNK VELESLLEGL TDEISFLRQL FEEETRELKS QISDTSAVLS
MDNSRSLDVD SIVAEVKAQC QEIANGSRAE AESVYQIKYE ELQTLAGKHG DDLWRTKTEI
SEMNRNISWL QAETEGLKGQ RASLEAAIID AEHRGEQALK DARAKRQQLE DAKQDMARQL
RDYQELMNVK LALDIEIATY RKLLEGEESR LESGMQNMSI HRKTTSGSAG GLSSAYGDLT
SPGLSYSLGS SFGSGGGSTF SRTSSTKAVV VKKIETHNGR LVSESSDVLP K
//
