ID   A0A2K6U8W5_SAIBB        Unreviewed;       449 AA.
AC   A0A2K6U8W5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=N-lysine methyltransferase SETD6 {ECO:0000256|ARBA:ARBA00016973, ECO:0000256|PIRNR:PIRNR011771};
DE            EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR011771};
GN   Name=SETD6 {ECO:0000313|Ensembl:ENSSBOP00000028310.1};
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000028310.1, ECO:0000313|Proteomes:UP000233220};
RN   [1] {ECO:0000313|Ensembl:ENSSBOP00000028310.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Protein-lysine N-methyltransferase.
CC       {ECO:0000256|PIRNR:PIRNR011771}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR011771}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
CC       {ECO:0000256|PIRNR:PIRNR011771}.
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DR   AlphaFoldDB; A0A2K6U8W5; -.
DR   STRING; 39432.ENSSBOP00000028310; -.
DR   Ensembl; ENSSBOT00000045190.1; ENSSBOP00000028310.1; ENSSBOG00000030542.1.
DR   GeneTree; ENSGT00940000153577; -.
DR   OMA; RVDWWLE; -.
DR   Proteomes; UP000233220; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:1904047; F:S-adenosyl-L-methionine binding; IEA:Ensembl.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR   GO; GO:0019827; P:stem cell population maintenance; IEA:Ensembl.
DR   CDD; cd19178; SET_SETD6; 1.
DR   Gene3D; 3.90.1420.10; Rubisco LSMT, substrate-binding domain; 1.
DR   Gene3D; 3.90.1410.10; set domain protein methyltransferase, domain 1; 1.
DR   InterPro; IPR011383; N-lys_methylase_SETD6.
DR   InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR   InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR044430; SETD6_SET.
DR   PANTHER; PTHR13271:SF34; N-LYSINE METHYLTRANSFERASE SETD6; 1.
DR   PANTHER; PTHR13271; UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE; 1.
DR   Pfam; PF09273; Rubis-subs-bind; 1.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF011771; RMS1_SET; 1.
DR   SUPFAM; SSF81822; RuBisCo LSMT C-terminal, substrate-binding domain; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000256|PIRNR:PIRNR011771};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR011771};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PIRNR:PIRNR011771};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR011771}.
FT   DOMAIN          38..262
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
SQ   SEQUENCE   449 AA;  50773 MW;  26E6EC952B5335AC CRC64;
     MATQAKRPRV AGPMACGDPD PVAGFLSWCR RVGLELSPKV EVSRQGTVAG YGMVARESVQ
     AGELLFVVPR AAILSPHTCS IGGLLERERG ALQSQSGWVP LLLALLHELQ AAASHWRPYF
     ALWPELGHLE HPMFWPEEER RRLLQGTGVP EAVEKDLDSI RSEYHSIVLP FMEAHPDLFS
     LRVHSLELYL QLVALVMAYS FQEPLEEEED EKEPNSPIMV PAADILNHLA NHNANLEYSA
     DCLRMVATQP IPKGHEIFNT YGQMANWQLI HMYGFVEPYP NNTDDTADIQ MVTVREAALQ
     GTKTEAERLL MYERWDFLCK LEMVGEEGAF VIGREEVLTE EELTTTLKVL CMPAEEFREF
     KDQDGGGDEK RGDGSLTITN IPKLKASWRQ LLRNSILLTL QTYATDLKTD KDVLSNKEAY
     AKLSWREQQA LQVRYGQKMI LHQLLEMTS
//