ID A0A2K6UAW6_SAIBB Unreviewed; 371 AA.
AC A0A2K6UAW6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=VPS37A subunit of ESCRT-I {ECO:0000313|Ensembl:ENSSBOP00000029062.1};
GN Name=VPS37A {ECO:0000313|Ensembl:ENSSBOP00000029062.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000029062.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000029062.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004633}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the VPS37 family.
CC {ECO:0000256|ARBA:ARBA00007617}.
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DR AlphaFoldDB; A0A2K6UAW6; -.
DR Ensembl; ENSSBOT00000045943.1; ENSSBOP00000029062.1; ENSSBOG00000030856.1.
DR GeneTree; ENSGT00950000183012; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0000813; C:ESCRT I complex; IEA:UniProt.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009056; P:catabolic process; IEA:UniProt.
DR GO; GO:0036258; P:multivesicular body assembly; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR009851; Mod_r.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR PANTHER; PTHR13678:SF2; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A; 1.
DR Pfam; PF07200; Mod_r; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 282..371
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51314"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 41391 MW; A0877C308B4D284F CRC64;
MSWLFPLTKS ASSSAAGSPS GLTSLQQQKQ RLIESLRNSH SRLLPPQFPQ EKPVISVYPP
IRHHLMDKQG VYVTSPLVNN FTMHSDLGKI IQSLLDEFWK NPPVLAPTST AFPYLYSNPS
AMPPYASQGF PFLSPYSPQE ANRSITSLSV ADTVSSSTSH TTAKPAAPSF GILSNLPLPV
PAMDASIPTS QNGFGYKMPD VPDAFPELSE LSVSQLTDMN EQEEVLLEQF LTLPQLKQII
TDKDDLVKSI EELARKNLLL EPSLEAKRQT VLDKYELLTQ MKSTFEKKMQ RQHELSESCS
ASALQARLKV AAHEAEEESD NIAEDFLEGK MEIDDFLSSF MEKRTICHCR RAKEEKLQQA
IAMHSQFHAP L
//
