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Database: UniProt
Entry: A0A2K6UEJ1_SAIBB
LinkDB: A0A2K6UEJ1_SAIBB
Original site: A0A2K6UEJ1_SAIBB 
ID   A0A2K6UEJ1_SAIBB        Unreviewed;       319 AA.
AC   A0A2K6UEJ1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=Nuclear receptor subfamily 1 group I member 3 {ECO:0000256|ARBA:ARBA00040912};
DE   AltName: Full=Constitutive androstane receptor {ECO:0000256|ARBA:ARBA00043125};
GN   Name=NR1I3 {ECO:0000313|Ensembl:ENSSBOP00000030322.1};
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000030322.1, ECO:0000313|Proteomes:UP000233220};
RN   [1] {ECO:0000313|Ensembl:ENSSBOP00000030322.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Binds and transactivates the retinoic acid response elements
CC       that control expression of the retinoic acid receptor beta 2 and
CC       alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital
CC       responsive element module of the human CYP2B6 gene and the CYP3A4
CC       xenobiotic response element. {ECO:0000256|ARBA:ARBA00037362}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR   RefSeq; XP_003938030.1; XM_003937981.2.
DR   AlphaFoldDB; A0A2K6UEJ1; -.
DR   STRING; 39432.ENSSBOP00000030322; -.
DR   Ensembl; ENSSBOT00000047207.1; ENSSBOP00000030322.1; ENSSBOG00000031387.1.
DR   GeneID; 101049831; -.
DR   KEGG; sbq:101049831; -.
DR   CTD; 9970; -.
DR   GeneTree; ENSGT00940000160641; -.
DR   OMA; VHAGFQE; -.
DR   OrthoDB; 5359733at2759; -.
DR   Proteomes; UP000233220; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:Ensembl.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR   CDD; cd06934; NR_LBD_PXR_like; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001728; ThyrH_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR   PANTHER; PTHR24082:SF231; NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 3; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00546; THYROIDHORMR.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          1..54
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          80..319
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
SQ   SEQUENCE   319 AA;  36438 MW;  88014DDD1B6681B3 CRC64;
     MLTRRSRRTV SKSIGPTCPF AGSCEVSKAQ RRHCPACRLQ KCLDAGMRKD MILSAEALAL
     RRAKQAQRRA QQTPMQLSKE QEELIRTLLG AHTRHVGTMF EQFVQFRPPA HLFIHHQPLP
     TLAPVLPLLT HFADVNTFMV QQVIKFTKDL PLFRSLPIED QISLLKGAAV EICHIALNTT
     FCLQTQNFLC GPLRYTIEDG ARVGFQVEFL ELLFHFHGTL RKLQLQEPEY VLLAAMALFS
     PDRPGVTQRD EIDQLQEEMA LTLQSYIKGQ QRRPRDRFLY AKLLGLLAEL RSINEAYGYQ
     IQRIQGLSAM MPLLQEICS
//
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