ID A0A2K6UEX8_SAIBB Unreviewed; 776 AA.
AC A0A2K6UEX8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Rac/Cdc42 guanine nucleotide exchange factor 6 {ECO:0000313|Ensembl:ENSSBOP00000030444.1};
GN Name=ARHGEF6 {ECO:0000313|Ensembl:ENSSBOP00000030444.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000030444.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000030444.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003940783.1; XM_003940734.2.
DR AlphaFoldDB; A0A2K6UEX8; -.
DR STRING; 39432.ENSSBOP00000030444; -.
DR Ensembl; ENSSBOT00000047329.1; ENSSBOP00000030444.1; ENSSBOG00000031501.1.
DR GeneID; 101050714; -.
DR KEGG; sbq:101050714; -.
DR CTD; 9459; -.
DR GeneTree; ENSGT00940000158723; -.
DR OMA; ITGNMVE; -.
DR OrthoDB; 2879064at2759; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
DR CDD; cd21265; CH_alphaPIX; 1.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12060; SH3_alphaPIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035788; AlphaPIX_SH3.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..111
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 160..219
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 241..421
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 443..548
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 115..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 718..759
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 116..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 87380 MW; 2BC0A9830D5EE009 CRC64;
MNPEEQIVTW LISLGVLDSP KKTICDPEEF LKSSLKNGVV LCKLINRLMS GSVEKFCLDP
QTEADCINNI NDFLKGCATL QVEVFDPDDL YSGVNFSKVL STLLAVNKAT EDQLSERPCG
RSSSLSAANT SQTNPQGAVS STASGLQRQS KTVEMTENGS HQLIVKARFN FKQTNEDELS
VCKGDIIYVT RVEEGGWWEG TLNGRTGWFP SNYVREIKSS ERPLSPKAVK GFETAPLTKN
YYTVVLQNIL DTEKEYAKEL QSLLVTYLRP LQSNNNLSTV EVMSLLGNFE EVCTFQQTLC
QALEECSKFP ENQHKVGGCL LSLMPHFKSM YLAYCANHPS AVNVLTQHSD ELEQFMENQG
ASSPGILILT TSLSKPFMRL EKYVTLLQEL ERHMEDTHPD HQDILKAIVA FKTLMGQCQD
LRKRKQLELQ ILSEPIQAWE GEDIKNLGNV IFMSQVMVQY GTCEEKEERY LMLFSNVLIM
LSASPRMSGF IYQGKIPIAG TVVARLDEIE GNDCTFEITG NTVERIVVHC NNNQDFQEWL
EQLNRLIRGP ASCSSLSKTS SSSCSAHSSF SSTGQPRGPL EPPQIIKPWS LSCLRPAPPL
RPSAALGYKE RMSYILKESS KSPKTMKKFL HKRKTERKPS EEEYAIRKST AALEEDAQIL
KVIEAYCTSA NFQQGHGSST RKDSIPQVLL PEEEKLIIEE TRSNGQTIME EKSLVDTVYA
LKDEVKELKQ ENKRMKQCLE EELKSRKDLE KLVRRLLKQT DECIRAESTS KTSILP
//
