ID A0A2K6UHH6_SAIBB Unreviewed; 1259 AA.
AC A0A2K6UHH6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Rho GTPase activating protein 33 {ECO:0000313|Ensembl:ENSSBOP00000031360.1};
GN Name=ARHGAP33 {ECO:0000313|Ensembl:ENSSBOP00000031360.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000031360.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000031360.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PX domain-containing GAP family.
CC {ECO:0000256|ARBA:ARBA00008795}.
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DR AlphaFoldDB; A0A2K6UHH6; -.
DR STRING; 39432.ENSSBOP00000031360; -.
DR Ensembl; ENSSBOT00000048248.1; ENSSBOP00000031360.1; ENSSBOG00000031839.1.
DR GeneTree; ENSGT00940000155110; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR CDD; cd11835; SH3_ARHGAP32_33; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF11; RHO GTPASE-ACTIVATING PROTEIN 33; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 186..248
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 315..510
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..771
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..897
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1125
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1181
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1207
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1259 AA; 134749 MW; 2BDA2BF31F04256D CRC64;
MVARSTDSLD GPGEGSVQPL PTAGGPSVKG KPGKRLSAPR GPFPRLADCA HFHYENVDFG
HIQLLLSPER EGPSLSGENE LVFGVQVTCQ GRSWPVLRSY DDFRSLDAHL HRCIFDRRFS
CLPELPPPPE GARAAQMLVP LLLQYLETLS GLVDSNLNCG PVLTWMELDN HGRRLLLSEE
ASLNIPAVAA AHVIKRYTAQ APDELSFEVG DIVSVIDMPP TEDRSWWRGK RGFQVGFFPS
ECVELFTERP GPGLKADADG TPCGIPAPQG ISSLTSAVPR PRGKLAGLLR TFMRSRPSRQ
RLRQRGILRQ RVFGCDLGEH LSNSGQDVPQ VLRCCSEFIE AHGVVDGIYR LSGVSSNIQR
LRHEFDSERI PELSGPAFLQ DIHSVSSLCK LYFRELPNPL LTYQLYGKFS EAMSVPGKEE
RLVRVHDVIQ QLPPPHYRTL EYLLRHLARM ARHSANTSMH ARNLAIVWAP NLLRSMELES
VGMGGAAAFR EVRVQSVVVE FLLTHVDILF SDTFTSAGLD PAGRCLLPRP KSLAGSCPST
RLLTLEEAQA RTQGRLGTPT EPTTPKAPAS PVERRKGERG EKQRKPGGSS WKTFFALGRG
PSVPRKKPLP WLGGTRAPPQ PSGGRPDTVT LRSAKSEESL SSQASGAGLQ RLHRLRRPHS
SSDAFPVGPA PAGSCESLSS SSSSSSSSSK SSSSSSESSA AGLGALSGSP SHRTSAWLDD
GDELDFSPPR CLEGLRGLDF DPLTFRCSSP TPGDPAPPAS PAPPAPASAF PPRVTPQAIA
PRGTTCPASP AALDISEPLA VTVPPAVLEL LGAGGTPASA TPTPALSPNR TLRPHLIPLL
LRGGEAPLTD TCQQETCSKL RGAQGGLGPD TESPLPPTHV SLLRPGGAPP PPPKNPARLM
ALALAERAQQ VAEQQSQQDC GGTPPAAQSP FRRSLSLEVG GEPPGTSGRM PAPNSLAHPG
AWVPGPPPYL PRQQSDGSML RSQRPMGTSR RGLRGPTQVP APGFFSPAPR ECLPPFLGVP
KPGLYPLGPP SFQPSSPATV WRSSLGPPVP LDRGENLYYE IGAGEGSPYS GPTRSWSPFR
SMPPDRLNAS YGMLGQSPPL HRSPDFLLNY PPTPSCFPPD PLGYSAPRHP ARRPTQPEPL
YVNLALGPRG PSPASSSSSS PPAHPRSRSD PGPPVPRLPQ KQRAPWGPRT PHRVPSPWGP
PEPLLLYRAA PPAYGTGGEL HRGSLYRSGG QRGEGAGPPP PYPTPSWSLH SEGQTRSYC
//
