ID A0A2K6UIV8_SAIBB Unreviewed; 465 AA.
AC A0A2K6UIV8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Pyrin and HIN domain family member 1 {ECO:0000313|Ensembl:ENSSBOP00000031878.1};
GN Name=PYHIN1 {ECO:0000313|Ensembl:ENSSBOP00000031878.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000031878.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000031878.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6UIV8; -.
DR STRING; 39432.ENSSBOP00000031878; -.
DR Ensembl; ENSSBOT00000048774.1; ENSSBOP00000031878.1; ENSSBOG00000032136.1.
DR GeneTree; ENSGT00390000013296; -.
DR OMA; TKQRSHD; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0002218; P:activation of innate immune response; IEA:InterPro.
DR GO; GO:0035457; P:cellular response to interferon-alpha; IEA:Ensembl.
DR GO; GO:0035458; P:cellular response to interferon-beta; IEA:InterPro.
DR GO; GO:1902164; P:positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:1900182; P:positive regulation of protein localization to nucleus; IEA:Ensembl.
DR GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR CDD; cd08305; Pyrin; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR040205; HIN-200.
DR InterPro; IPR004021; HIN200/IF120x.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR12200; INTERFERON-INDUCIBLE PROTEIN AIM2 FAMILY MEMBER; 1.
DR PANTHER; PTHR12200:SF25; PYRIN AND HIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF02760; HIN; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF159141; HIN-2000 domain-like; 2.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50834; HIN_200; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 1..88
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 192..392
FT /note="HIN-200"
FT /evidence="ECO:0000259|PROSITE:PS50834"
FT REGION 87..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 465 AA; 52157 MW; FB060A06E5812B4E CRC64;
MANSYKTIVL LKGLEVINDY HFRMVKSLLS NDLKLNSKMR DEYDKIQIAD LMEEKFPGDA
GLGRLIEIFK EIPTLGNLAE TLKKEKLKVK GKTPSKKQQQ NEVDPATPES TPSNILTAEG
AEETPGAQKR KNSSEEETGT KRSKMAKEQT QPPCPTEAGM STARSHSPPP QPSSSTPSNT
SSAEAQSLRP LVRRQATARK NICPKDPMMV MVLNATKIFK YESSQNKRRR MFHATVVTQT
EFFHVKVLNI NLKRKFTKKR IIIISNYSKY NSLLEVNEAS SVFEAGPDQT FQVPKDIIKR
ARKTPKINML HKQASGDIVY GLFTLHDKNI KRKVTIYEIL DETGSMNVVG KGECHNISCE
KGDKLQLFCF RLRKRKDELQ LMSEMHSFIQ IRKKTKQRSH DSSSMALSQE QSQLPKPSEA
GTTLPLECHL IKTLQGLSTT PSSSSFTKDT TTQTSAPSSA NCTGE
//
