ID A0A2K6UKY2_SAIBB Unreviewed; 1851 AA.
AC A0A2K6UKY2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Myosin heavy chain 8 {ECO:0000313|Ensembl:ENSSBOP00000032522.1};
GN Name=MYH8 {ECO:0000313|Ensembl:ENSSBOP00000032522.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000032522.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000032522.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 39432.ENSSBOP00000032522; -.
DR Ensembl; ENSSBOT00000049424.1; ENSSBOP00000032522.1; ENSSBOG00000032438.1.
DR GeneTree; ENSGT00940000161785; -.
DR OMA; TMDMEND; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0000146; F:microfilament motor activity; IEA:Ensembl.
DR GO; GO:0046034; P:ATP metabolic process; IEA:Ensembl.
DR GO; GO:0030049; P:muscle filament sliding; IEA:Ensembl.
DR GO; GO:0003009; P:skeletal muscle contraction; IEA:Ensembl.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF35; MYOSIN-8; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Thick filament {ECO:0000256|ARBA:ARBA00022433}.
FT DOMAIN 35..84
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 88..781
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 658..680
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 801..1840
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 181..188
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1851 AA; 212475 MW; 070A9A9C724D15FE CRC64;
MSASSDAEMA VFGEAAPYLR KSEKERIEAQ NKPFDAKTSV FVAEPKESYV KSTIQSKEGG
KVTVKTEGGA TLTVKEDQVF PMNPPKYDKI EDMAMMTHLH EPGVLYNLKE RYAAWMIYTY
SGLFCVTVNP YKWLPVYNPE VVAAYRGKKR QEAPPHIFSI SDNAYQFMLT DRENQSILIT
GESGAGKTVN TKRVIQYFAT IAVTGEKKKD ESRKMQGTLE DQIISANPLL EAFGNAKTVR
NDNSSRFGKF IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QITSNKKPDL
IEMLLITTNP YDYAFVSQGE IIVPSIDDQE ELMATDSAID ILGFTPEEKV SIYKLTGAVM
HYGNMKFKQK QREEQAEPDG TEVADKAAYL QSLNSADLLK ALCYPRVKVG NEYVTKGQTV
QQVYNAVGAL AKAVYEKMFL WMVTRINQQL DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC
INFTNEKLQQ FFNHHMFVLE QEEYKKEGIE WTFIDFGMDL AACIELIEKP LGIFSILEEE
CMFPKATDTS FKNKLYDQHL GKSANFQKPK VVKGKAEAHF SLIHYAGTVD YNITGWLDKN
KDPLNDTVVG LYQKSAMKTL ASLFSTYASA EADSSAKKGT KKKGSSFQTV SALFRENLNK
LMTNLRSTHP HFVRCIIPNE TKTPGAMEHE LVLHQLRCNG VLEGIRICRK GFPSRILYGD
FKQRYKVLNA SAIPEGQFID SKKASEKLLA SIDIDHTQYK FGHTKVFFKA GLLGLLEEMR
DDKLAQIITR TQAVCRGFLM RVEYQKMLQR EADSLADAEE RCEQLIKNKI QLEAKIKEVT
ERAEEEEEIN AELTAKKRKL EDECSELKKD IDDLELTLAK VEKEKHATEN KVKNLTEEMA
GLDETIAKLT KEKKALQEAH QQTLDDLQAE EDKVNTLTKA KSKLEQQVDD LEGSLEQEKK
LRMDLERAKR KLEGDLKLAQ ESTMDIENDK QQLDEKLKKK EFEISNLISK IEDEQAVEIQ
LQKKIKELQA RIEELEEEIE AERASRAKAE KQRSDLSQEL EEISERLEEA GGATSAQVEL
NKKREAEFQK LRRDLEEATL QHEATGAALR KKHADSMAEL GEQIDNLQRV KQKLEKEKSE
LKMEIDDLSS NAEAISKAKG NLEKMCRTLE DQVSELKTKE EEQQRLINDL TAQRARLQTE
AGEYSRQLDE KDALVSQLSR SKQASTQQIE ELKRQLEEET KAKNALAHAL QSSRHDCDLL
REQYEEEQEG KAELQRALSK ANTEVAQWRT KYETDAIQRT EELEEAKKKL AQRLQEAEEH
VEAVNAKCAS LEKTKQRLQN EVEDLMLDVE RSNAACAALD KKQRNFDKVL SEWKQKYEET
QAELEASQKE SRSLSTELFK VKNAYEESLD QLETLRRENK NLQQEISDLT EQIAEGGKQI
HELEKIKKQV EQEKCEIQAA LEEAEASLEH EEGKILRIQL ELNQVKSEVD RKIAEKDEEI
DQLKRNHIRV VETMQSTLDA EIRSRNDALR VKKKMEGDLN EMEIQLNHAN RLAAESLRNY
RNTQGMLKET QLHLDDALRC QEDLKEQLAI VERRANLLQA EIEELRATLE QTDRSRKIAE
QELLDASERV QLLHTQNTSL INTKKKLEND VSQLQSEMEE VIQESRNAEE KAKKAITDAA
MMAEELKKEQ DTSAHLERMK KNLEQTVKDL QHRLDEAEQL ALKGGKKQIQ KLEARVRELE
GEVENEQKRN AEAVKGLRKH ERRVKELTYQ TEEDRKNVLR LQDLVDKLQA KVKSYKRQAE
EAEEQSNANL AKFRKLQHEL EEAEERADIA ESQVNKLRVK SREVHTKISA E
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