ID A0A2K6UNG0_SAIBB Unreviewed; 1014 AA.
AC A0A2K6UNG0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=DAB2 interacting protein {ECO:0000313|Ensembl:ENSSBOP00000033392.1};
GN Name=DAB2IP {ECO:0000313|Ensembl:ENSSBOP00000033392.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000033392.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000033392.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6UNG0; -.
DR Ensembl; ENSSBOT00000050306.1; ENSSBOP00000033392.1; ENSSBOG00000032859.1.
DR GeneTree; ENSGT00940000155853; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF26; DISABLED HOMOLOG 2-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 1..78
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 69..187
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 247..439
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 529..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..786
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..889
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1014 AA; 111856 MW; D49DD7981FDE4CD5 CRC64;
MPRLKESRSH ESLLSPSSAV EALDLSMEEE VVIKPVHSSI LGQDYCFEVT TSSGSKCFSC
RSAAERDKWM ENLRRAVHPN KDNSRRVEHI LKLWVIEAKD LPAKKKYLCE LCLDDVLYAR
TTGKLKTDNV FWGEHFEFHN LPPLRTVTVH LYRETDKKKK KERNSYLGLV SLPAASVAGR
QFVEKWYPVV TPNPKGGKGP GPMIRIKARY QTITILPMEM YKEFAEHITN HYLGLCAALE
PILSAKTKEE MASALVHILQ STGKVKDFLT DLMMSEVDRC GDNEHLIFRE NTLATKAIEE
YLKLVGQKYL QDALGEFIKA LYESDENCEV DPSKCSAADL PEHQGNLKMC CELAFCKIIN
SYCVFPRELK EVFASWRQEC SSRGRPDISE RLISASLFLR FLCPAIMSPS LFNLLQEYPD
DRTARTLTLI AKVTQNLANF AKFGSKEEYM SFMNQFLEHE WTNMQRFLLE ISNPETLSNT
AGFEGYIDLG RELSSLHSLL WEAVSQLEQS IVSKLGPLPR ILRDVHTALS TPGSGQLPGT
NDLASTPGSG SSSISAGLQK MVIENDLSGS SGVQPSPARS SSYSEANEPD LQMANGGKSL
SMVDLQDARA LDGEAGSPAG PDVLPTDGQA PAAQLVAGWP ARATPVSLTG LATVRRAGQT
PTTPGTSEGA PGRPQLLAPL SFQNPVYQMA AGLPLSPRGL GDSGSEGHSS LSSHSNSEEL
AAAAKLGSFS TAAEELARRP GELARRQMSL TEKGGQPTMP RQNSAGPQRR IDQPPPPPPP
PHTLKTGRTP PNLLSTLQYP RPSSGTLASA SPDWAGPSAR LRQQSSSSKG DSPELKPRAV
HKQGPSPVSP NALDRTAAWL LTMNAQLLED EGLGPDPPHR DRLRSKDELS QAEKDLAVLQ
DKLRISTKKL EEYETLFKCQ EETTQKLVLE YQARLEEGEE RLRRQQEDKD IQMKGIISRL
MSVEEELKKD HAEMQAAVDS KQKIIDAQEK RIASLDAANA RLMSALTQLK ESMH
//
