ID A0A2K6USY4_SAIBB Unreviewed; 1664 AA.
AC A0A2K6USY4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=SH3 and multiple ankyrin repeat domains 2 {ECO:0000313|Ensembl:ENSSBOP00000035026.1};
GN Name=SHANK2 {ECO:0000313|Ensembl:ENSSBOP00000035026.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000035026.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000035026.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
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DR Ensembl; ENSSBOT00000051952.1; ENSSBOP00000035026.1; ENSSBOG00000033655.1.
DR GeneTree; ENSGT00940000153561; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09506; SAM_Shank1_2_3; 1.
DR CDD; cd11983; SH3_Shank2; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24135:SF17; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 2; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT REPEAT 29..62
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 63..95
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 130..162
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 163..195
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 359..418
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 459..553
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1601..1664
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 291..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1256..1287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1449..1478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1494..1591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..724
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1257..1285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1494..1560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1575..1591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1664 AA; 180202 MW; F6E3887711A9A6D7 CRC64;
MDHIQHRSVE KIAKMLDRGL DPNFHDLETG ETPLTLAAQL DHSVEVIKAL RNGGAHLDFR
AKDGMTALHK AARARNQVAL KTLLELGASP DYKDSYGLTP LYHTAIVGGD PYCCELLLHE
HAMVCCKDEN GWHEIHQACR YGHVQHLEHL LFYGADMSAQ NASGNTALHI CALYNQDSCA
RVLLFRGGNK ELKNYNSQTP FQVAIIAGNF ELAEYIKNHK ETDVVPFREA PAYSNRRRRP
PNTLAAPRVL LRSNSDNNLN ASAPEWAVCS TGTSNRSLSP QLLQQMPSKP EGAAKTIGSY
VPGPRSRSPS LNRLGGAGED GKRLQPLWHV GSPFVPAANK DSPLAFEYPG PKRKLYSAVP
GRLFVVIKPY QPQVDGEIPL HRGDRVKVLS IGEGGFWEGS ARGHIGWFPA ECVEEVQCKP
RDSQAETRAD RSKKLFRHYT VGSYDSFDTT SDCIIEEKTV VLQKKDNEGF GFVLRGAKAD
TPIEEFTPTP AFPALQYLES VDEGGVAWQA GLRTGDFLIE VNNENVVKVG HRQVVNMIRQ
GGNHLVLKVV TVTRNLDPDD TARKKAPPPP KRAPTTALTL RSKSMTSELE ELDKPEEIVP
ASKPSRAAEN MAVEPRVATI KQRPSSRCFP AGSDINSVYE RQGIAVMTPT VPGSPKAPFL
GLPRGTMRRQ KSIGITEEER QFLAPPMLKF TRSLSMPDTS EDIPPPPQSV PPSPPPPSPT
TYNCPKSPTP RVYGTIKPAF NQNSAAKMSP ATRSDTVATM MREKGMYFRR ELDRYSLDSE
DLYNRNAGPQ ANFRNKRGQM PENPYSEVGK IASKAVYVPA KPARRKGMLV KQSNVEDSPE
KTCSIPIPTI IVKEPSTSSS GKSSQGSSME IDPQAPEPPG QLRPDESLTV SSPFAAAIAG
AVRDREKRLE ARRNSPAFLS TDLGDEDVGL GPPASRTRPS MFPEEESFAD EDGAEQLSSP
MPGAVPREPE NHFMGGTEAS AQGEAGRALN STSKAQGPES SPVVPPTSGG TAGPGNYVHP
LTGRLLDPSS PLALALSARD RAMKESQQGP KGEAPKADLN KPLYIDTKMR PNLDAGFPTA
ARPNTRGPLR RQETENKYET DLGRDRKGDD KKNMLIDIMD TSQQKSAGLL MVHTVDAAKL
DNALQEEDEK ADVEVKPDGS PSGVPEGVSE TEGALQISAA PEPTAVPGRA LVAVGSMEEA
VILPFRIPPP PLASVDLDED FIFTEPLPPP LEFANSFDIP DDRAASVPAL TDLVKQKKND
TPPSPALNSS QPTNSADSKK PASLSNCLPA SFLPPPESFD AVADSGIEEV DSRSSSDHHL
ETTSTISTVS SISTLSSEGG ENVDTCTVYA DGQAFMVDKP PVPPKPKVKP IIHKSNALYQ
DALVEEDVDS FVIPPPAPPP PPGSAQPGMA KILQPRTSKL WGDVTEIKSP ILSGPKANVI
SELNSILQQM NREKSAKPGE GLDSPTGAKS ASLAPRSPEI MSTISGTRST TVTFTVRPGT
SQPITLQSRP PDYESRTSGT RRAPSPVVSP TETNKEILPT PLSAAASPSP TLSDVFSLPS
QPPSGDLFGL NPVGRSRSPS PSILQQPISN KPFTTKPVHL WTKPDVADWL ESLNLGEHKE
AFMDNEIDGS HLPNLQKEDL IDLGVTRVGH RMNIERALKQ LLDR
//
