ID   A0A2K6UTX8_SAIBB        Unreviewed;       765 AA.
AC   A0A2K6UTX8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO9 {ECO:0000313|Ensembl:ENSSBOP00000035302.1};
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000035302.1, ECO:0000313|Proteomes:UP000233220};
RN   [1] {ECO:0000313|Ensembl:ENSSBOP00000035302.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; A0A2K6UTX8; -.
DR   STRING; 39432.ENSSBOP00000035302; -.
DR   Ensembl; ENSSBOT00000052231.1; ENSSBOP00000035302.1; ENSSBOG00000033810.1.
DR   GeneTree; ENSGT00940000158300; -.
DR   OMA; KTWARWR; -.
DR   Proteomes; UP000233220; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:Ensembl.
DR   GO; GO:0017128; F:phospholipid scramblase activity; IEA:Ensembl.
DR   GO; GO:0061591; P:calcium activated galactosylceramide scrambling; IEA:Ensembl.
DR   GO; GO:0061590; P:calcium activated phosphatidylcholine scrambling; IEA:Ensembl.
DR   GO; GO:0061589; P:calcium activated phosphatidylserine scrambling; IEA:Ensembl.
DR   GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF37; ANOCTAMIN-9; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        190..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        270..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        335..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        377..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        427..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        579..603
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        679..708
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          182..719
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   765 AA;  88097 MW;  52C840DE9C208F0F CRC64;
     MDGQDPQLYP HTPILVEPEG DSFPLMDFSP CETEASEQWD YVLAADLRTQ TDPRRVQQQR
     QFLEELRRKG FHTKMIKDQK QVFFGIRADH SVFDLYHTLL LEPEGPARHA EQAEATAVPV
     TTRIRIVNFV VQKNKTSAGK TFESLVKDGV FEAKFPLHKE EENLKTWAQW RSMFRKQPVD
     DIRNYFGEKV ALYFAWLGWY TYMLVPAALT GLVVFLSGFS LFEASQISKE ICEADDILMC
     PLGDRSRRFQ RLSDTCTFAK LTHLFDNDGT VVFAIFMALW ATVFLEIWKR QRASVVLHWN
     LYVWDEDQEE MALELINCPS YELQLHQHSY LRSTVIFVLT LLMISLMIGM AHLLVVYRVL
     ASALCSSPAL AFLEEQVTTA VVVTGALVHY VTIVVMTKAN KLVALKLCDF EKPRTFSERE
     SRFTTRFFTL QFFAHFSSLI YIAFILGRIN GHPGKSTRLA GLWKLEECHA SGCMMDLFVQ
     MAIIMGLKQT LSNCVEYLGP WLAHKLRSKQ ASAPAGNPEL RDWQRNYLLN PVNTFSLFDE
     FMEMSAWALG AGNLVEIRLD AIKMVRLQRR LVPRKAKDIG TWLQVLETIG VLAVIANGMV
     IAFTSEFIPR VVYKYRYSPC LKEANSTVDC LTGYVNHSLS VFYTKDFQDP DGIEGSENVT
     HCRYRDYRHP HHYTLTRKFW FLLAIRLAFV ILFEHVALCI KLIAAWFVPD VPQSVKNRVL
     EIKYQRLREK MRERQRLGRV QMGPQPPTPT YPTPASIFSA RSTDV
//