ID   A0A2K6UX16_SAIBB        Unreviewed;      1059 AA.
AC   A0A2K6UX16;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752};
DE            EC=3.2.1.24 {ECO:0000256|ARBA:ARBA00012752};
GN   Name=MAN2C1 {ECO:0000313|Ensembl:ENSSBOP00000036398.1};
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000036398.1, ECO:0000313|Proteomes:UP000233220};
RN   [1] {ECO:0000313|Ensembl:ENSSBOP00000036398.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
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DR   AlphaFoldDB; A0A2K6UX16; -.
DR   STRING; 39432.ENSSBOP00000036398; -.
DR   Ensembl; ENSSBOT00000053330.1; ENSSBOP00000036398.1; ENSSBOG00000034236.1.
DR   GeneTree; ENSGT01030000234638; -.
DR   OMA; GQYWDAW; -.
DR   Proteomes; UP000233220; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   GO; GO:0009313; P:oligosaccharide catabolic process; IEA:Ensembl.
DR   CDD; cd10813; GH38N_AMII_Man2C1; 1.
DR   Gene3D; 2.60.40.2220; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT   DOMAIN          519..598
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
FT   REGION          688..707
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        693..707
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1059 AA;  116851 MW;  0AAEF5DCBDCEA4D3 CRC64;
     TAMAAAPALK HWRATLERVE KFVSPLYFTD CNLRGRLFGA SCPVAALSSF LTAERLPYQE
     AVQQAFRPAQ VGDSFGPTWW TCWFRVELTI PEAWVGQEVH LRWESDGEGL VWRDGEPVQG
     LTKEGEKTSY VVTDRLGEGD PRSLTLYVEV ACNGLLGAGK GSMIAAPDPE KMFQLSRAEL
     AVFHRDVHNL LVDLELLLGI AKGLGEGNQR SFQALYTANQ MVNMCDPAQP ETFPVAQALA
     SRFFGQRGGE SQHTIHATGH CHIDTAWLWP FKETVRKCAR SWVTALKLME RNPEFIFACS
     QAQQLEWVKS HYPGLYSRLQ EFASRGQFVP VGGTWVEMDG NLPSGEAMVR QFMQGQNFFL
     QEFGKMCSEF WLPDTFGYSA QLPQIMRGCG IRRFLTQKLS WNLVNSFPHH TFFWEGLDGS
     RVLVHFPPGD SYGMQGSVEE VLKTVANNRD KGRANHSAFL FGFGDGGGGP TQTMLDRLRR
     LSNTDGLPRV QLSSPRKLFS ALESGSGQLC TWVGELFLEL HNGTYTTHAQ IKKGNRECER
     ILHDVELLSS LALARSAQFL YPAAQLQHLW RLLLLNQFHD VVTGSCIQMV AEDALRHYED
     IRSHGNTLLS NAAAALCAGE PGPEGLLIAN TLPWTRTEVM ALPKPGGAHS LGLTPSSGDS
     AQHGLCSCSR PHFAAAPAAP AACVRSAGAP ANSASRPPPT KTDGSVTLDN GIIRVKLDPT
     GRLTSLVLVA SGREAIAEGA AGNQFVLFDD VPLYWDAWDV MDYHLETRKP VLGQPGTLAV
     GTEGGLRGSA WFLLQISPNS RLSQEVVLDV GCPYVRFHTE VHWHEAHKFL KVEFPARVRS
     SQATYEIQFG HLQRPTHYNT SWDWARFEVW AHRWMDLSEH GFGLALLNDC KYGASVRGST
     LSLSLLRAPK APDATADMGR HEFTYALMPH KGSFQDAGVI QAAYSLSFPL LALPAPGPAP
     ATSWSAFSLS SPAVVLETVK QAESSPQSRS LVLRLYESHG SHVDCWLHLS LPVQEAVLCD
     LLERPDPAGH LPLRDNRLKL TFSPFQVLSL LLVLQPPPH
//