ID A0A2K6UXE9_SAIBB Unreviewed; 1089 AA.
AC A0A2K6UXE9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Rap guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSSBOP00000036586.1};
GN Name=RAPGEF1 {ECO:0000313|Ensembl:ENSSBOP00000036586.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000036586.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000036586.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6UXE9; -.
DR Ensembl; ENSSBOT00000053520.1; ENSSBOP00000036586.1; ENSSBOG00000034342.1.
DR GeneTree; ENSGT00940000156235; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 844..966
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 996..1089
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..277
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1089 AA; 119521 MW; 320633C818FEA69D CRC64;
MKLMDKFHSP KIKRTPSKKG KPAEVSVKIP EKPVNKEATD RFLPEGYPLP LDLEQQAVEF
MSTSAVASRS QRQKNLSWLE EKEKEVVSAL RYFKTIVDKM AIDKKVLEML PGSASKVLEA
ILPLVQSDPR IQHSSALSSC YSRVYQSLAN LIRWSDQVML EGVNSEDKEM VTTVKGVIKA
VLDGVKELVR LTIEKQGRPS PTSPVKPSSP AGKPDGPAEL PLTDREVEIL NKTTGMSQST
ELLPDATDEE VAPPKPPLPG IRVVDNSPPP ALPPKKRQSA PSPTRVAVVA PMSRATSGSS
LPVGINRQDF DIDCYAQRRL SGGSHSYGGE SPRLSPCSSI GKLSKSDEQL SSLDRDSGQC
SRNTSCETLD HYDPDYEFLQ QDLSNADQIP QQTAWSLSPL PESLGESGSP FLGHPFQLPL
GNHPQPDGAL APGQQTDTPP ALPEKKRRSA ASQTADSSGC RVSFERHPSQ YDNISGEDLQ
STAPVQPVTY APFAAILPFQ HGGSSAPVEF VGDFTAPEST GDPEKPPPLP EKKNKHMLAY
MQLLEDYSEP QPSMFYQTPQ NEHIYQQKNK LLMEVYGFSD SFTGADSVQE LAPPPALPPK
QRQLQASCAA ASFSSVSYCV QQTKVAFTPE DGSAAQGLSV SVSNSFLSRH GSLPVPSYKS
VFRSYSQDFV PHHQASVPPF LPPTSSSSPH FPPVHQSQSS DLAVPTIAGP PPSTVDGPLS
ASQESSFHGN TVCLPSETSF TDSSENASEE AGEGEYVNLY SSGQSSEELA PPRGDPPAGK
DGHPRDPTAV GSVPGKDSRD GSERAPKSPD ALESAQSEEE VDELSLIDHS EIMSRLTLKQ
EGDDGPDVRG GSGDILLVHA TETDRKDLVL YCEAFLTTYR TFISPEELIK KLQYRYEKFS
PFADTFKKRV SKNTFFVLVR VVDELCLVEL TEEILKLLME LVFRLVCNGE LSLARVLRKN
ILDKVDQKKL LRCATSGQPL AARGVAARPG TLHDFHSHEI AEQLTLLDAE LFYKIEIPEV
LLWAKEQNEE KSPNLTQFTE HFNNMSYWVR SIIMLQEKAQ DRERLLLKFI KIMKVMVARS
SPDPHQSLH
//
