ID A0A2K6UXM3_SAIBB Unreviewed; 4789 AA.
AC A0A2K6UXM3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSSBOP00000036661.1};
GN Name=RYR3 {ECO:0000313|Ensembl:ENSSBOP00000036661.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000036661.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000036661.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671,
CC ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00036634};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR Ensembl; ENSSBOT00000053596.1; ENSSBOP00000036661.1; ENSSBOG00000033211.1.
DR GeneTree; ENSGT00940000155507; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF9; RYANODINE RECEPTOR 3; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4110..4134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4338..4358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4406..4425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4531..4549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4592..4613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4672..4695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..147
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 154..199
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 207..261
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 267..325
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 577..788
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1004..1200
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1246..1458
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3846..3881
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 2217..2236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3283..3302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4029..4048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4215..4283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4241..4283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4789 AA; 543921 MW; B9DDBBE1373BEE1C CRC64;
MFGSLFSRQE DEVVLQCIAT IHKEQRKFCL AAEGLGNRLC FLEPTSEAKY IPPDLCVCSF
VLEQSLSVRA LQEMLANTGE NGGEGAAQGG GHRTLLYGHA ILLRHSFSGM YLTCLTTSRS
QTDKLAFDVG LREHATGEAC WWTIHPASKQ RSEGEKVRIG DDLILVSVSS ERYLHLSVSN
GNIQVDASFM QTLWNVHPTC SGSSIEEGYL LGGHVVRLFH GHDECLTIPS TDQNDSQHRR
IFYEAGGAGT RARSLWRVEP LRISWSGSNI RWGQAFRLRH LTTGHYLALT EDQGLILQDR
AKSDTKSTAF SFRASKEIKE KLDSSHKRDI EGMGVPEIKY GDSVCFVQHI ASGLWVTYKA
QDVKTSRLGP LKRKVILHQE GHMDDGLTLQ RCQREESQAA RIIRNTTALF SQFVSGNNRT
AAPIALPIEE VLQTLQDLIA YFQPPEEEMR HEDKQNKLRS LKNRQNLFKE EGMLALVLNC
IDRLNIYNSV AHFAGIAREE SGMAWKEILN LLYKLLAALI RGNRNNCAQF SNNLDWLISK
LDRLESSSGI LEVLHCILTE SPEALNLIAE GHIKSIISLL DKHGRNHKVL DILCSLCLCN
GVAVRANQNL ICDNLLPQRN LLLQTRLIND VTSIRPNIFL GVAEGSAQYK KWYFELIIDQ
VDPFLTAEPT HLRVGWASSS GYAPYPGGGE GWGGNGVGDD LYSYGFDGLH LWSGRIPRAV
ASINQHLLRS DDVVSCCLDL GVPSISFRIN GQPVQGMFEN FNTDGLFFPV MSFSAGVKVR
FLMGGRHGEF KFLPPSGYAP CYEALLPKEK MRLEPVKEYK RDADGVRDLL GTTQFLSQAS
FIPCPIDTSQ VVLPPHLEKI RDRLAENIHE LWGMNKIELG WTFGKIRDDN KRQHPCLVEF
SKLPETEKNY NLQMSTETLK TLLALGCHIA HVNPAAEEDL KKVKLPKNYM MSNGYKPAPL
DLSDVKLLPP QEILVDKLAE NAHNVWAKDR IKQGWTYGIQ QDLKNKRNPR LVPYALLDER
TKKSNRDSLR EAVRTFVGYG YNVEPSDQEL ADPAVEKVSI DKIRFFRVER SYAVRSGKWY
FEFEVVTGGD MRVGWARPGC RPDVELGADD QAFVFEGSRG QRWHQGSGYF GRTWQPGDVV
GCMINLDDAS MIFTLNGELL ITNKGSELAF ADYEIENGFV PICCLGLSQI GRMNLGTDAS
TFKFYTMCGL QEGFEPFAVN MNRDVAMWFS KRLPTFVNVP KDHPHIQVMR IDGTMDSPPC
LKVTHKTFGT QNSNADMIYC RLSMPVECHS SFSHSPCLDS EAFQKRKQMQ EILSHTTTQC
YYAIRIFAGQ DPSCVWVGWV TPDYHLYSEK FDLNKNCTVT VTLGDERGRV HESVKRSNCY
MVWGGDIVAS SQRSNRSNVD LEIGCLVDLA MGMLSFSANG KELGTCYQVE PNTKVFPAVF
LQPTSTSLFQ FELGKLKNAM PLSAAIFKSE EKNPIPQCPP RLDVQTIQPV LWSRMPNSFL
KVETERVSER HGWLVQCLEP LQMMALHIPE ENRCVDILEL CEQEDLMCFH YHTLRLYSAV
CALGNSRVAY ALCSHVDLSQ LFHAIDNKYL PGLLRSGFYD LLISIHLANA KERKLMMKNE
YIIPITSTTR NIRLFPDESK RHGLPGVGLR TCLKPGFRFS TPCFVMTGEE HQKQSPEIPL
ESLRTKALSM LTEAVQCSGA HIRDPVGGSV EFQFVPVLKL IGTLLVMGVF DDDDVRQILL
LVDPSVFGEH SAETEEGAEK EEVTQVEEKA VEAGEKASKE APVKGLLQTR LPESVKLQMC
ELLSYLCDCE LQHRVEAIVA FGDIYVSKLQ ANQKFRYNEL MQALNMSAAL TARKTKEFRS
PPQEQINMLL NFQLGENCPC PEEIREELYD FHEDLLIHCG VPLEEEKEEE EDTSWTGKLR
ALVYKIKGPP NPEKEQPTEE EERCPTTLKE LISQTMICWA QEDQIQDAEL VRMMFNLLRR
QYDSIGELLQ ALRKTYTISH ASVSDTINLL AALGQIRSLL SVRMGKEEEL LMINGLGDIM
NNKVFYQHPN LMRVLGMHET VMEVMVNVLG TEKSQIAFPK MVASCCRFLC YFCRISRQNQ
KAMFEHLSYL LENSSVGLAS PSMRGSTPLD VAASSVMDNN ELALGLEEPD LEKVVMYLAG
CGLQSCPMLL AKGYPDVGWN PIEGERYLSF LRFAVFVNSE SQVFSIPFIP RIRNRRENQP
FSHPPSVGSF SSTEDDEEEE EIVHMGNAIM SFYSALIDLL GRCAPEMHLI QTGKGEAIRI
RSILRSLVPT EDLVGIISIP LKLPSLNKDG SVSEPDMAAN FCPDHKASMV LFLDRVYGIK
DQTFLLHLLE VGFLPDLRAS ASLDTVSLST TEAALALNRY ICSAVLPLLT RCAPLFAGTE
HCTSLIDSTL QTIYRLSKGR SLTKAQRDTI EECLLAICNH LRPSMLQQLL RRLVFDVPQL
NEYCKMPLKL LTNHYEQCWK YYCLPSGWGS YGLAVEEELH LTEKLFWGIF DSLSHKKYDP
DLFRMALPCL SAIAGALPPD YLDTRITATL EKQISVDADG NFDPKPINTM NFSLPEKLEY
IVTKYAEHSH DKWACDKSQN GWKYGISLDE NVKTHPLIRP FKTLTEKEKE MYRWPARESL
KTMLAVGWTV ERTKEGEALV QQRENEKLRS VSQASQGNSY SPAPLDLSNV VLSRELQGMV
EVVAENYHNI WHPLKKLSWE VQRKSQIHPL LVPYDTLTAK EKFKDREKAQ DLFKFLQVNG
VIVSRGMKDM ELDASSMEKR FAYKFLKKIL KYVDSAQEFI AHLEAIVSSG KTEKSPHDQE
IKFFAKVLLP LVDQYFTNHH LYFLSSPLKP LSSSGYASHK EKEMVIFFIL GSDSTTMVSC
LHILAQTLDT RTVMKSGSEL VKAGLRAFFE NAAEDLEKTS ENLKLGKFTH SRTQIKGVSQ
NINYTTVALL PILTSIFEHV AQHQFGMDLL LGDVQISCYH ILCSLYSLGT GKNIYVERQR
PALGECLASL AAAIPVAFLE PTLNRYNPLS VFNTKTPRER SILGMPDTVE DMCPDIPQLE
GLMKEINDLA ESGARYTEMP HVIEVILPML CNYLSYWWER GPENLPPSTG PCCTKVTSEH
LSIILGNILK IINNNLGIDE ASWMKRIAVY AQPIISKARP DLLRSHFIPT LEKLKKKAVK
TVQEEEQLKA DGKGDTQEAE LLILDEFAVL CRDLYAFYPM LIRYVDNNRS NWLKSPDADS
DQLFRMVAEV FILWCKSHNF KREEQNFVIQ NEINNLAFLT GDSKSKMSKS GGQDQERKKT
KRRGDLYSIQ TSLIVAALKK MLPIGLNMCT PGDQELISLA KSRYSHRDTD EEVREHLRNN
LHLQEKSDDP AVKWQLNLYK DVLKSEEPFN PEKTVERVQR ISAAVFHLEQ VEQPLRSKKA
VWHKLLSKQR KRAVVACFRM APLYNLPRHR SINLFLHGYQ RFWIETEEYS FEEKLVQDLA
KSPKVEEEEE EETEKPPDPL HQIILYFSRN ALTERRSEPP EHLLLPGTKD TGEKEMEKQK
TLYQQARLHE RGAAEMVLQM ISSSKGEMSP MVVETLKLGI AILNGGNAGV QQKMLDYLKE
KKDAGFFQSL SGLMQSCSVL DLNAFERQNK AEGLGMVTEE GTLIVRERGK FEFLNDEFTR
DLFRFLQLLC EGHNSDFQNF LRTQMGNTTT VNVIISTVDY LLRLQESISD FYWYYSGKDI
IDESGQHNFS KALAVTKQIF NSLTEYIQGP CIGNQQSLAH SRLWDAVVGF LHVFANMQMK
LSQDSSQIEL LKELLDLLQD MVVMLLSLLE GNVVNGTIGK QMVDTLVESS TNVEMILKFF
DMFLKLKDLT SSDTFKEYDP DGKGIISKKE FQKAMEGQKQ YTQSEIDFLL SCAEADENDM
FNYIDFVDRF HEPAKDIGFN VAVLLTNLSE HMPNDSRLKC LLDPAESVLS YFEPYLGRIE
IMGGAKKIER VYFEISESSR TQWEKPQVKE SKRQFIFDVV NEGGEQEKME LFVNFCEDTI
FEMQLASQIS ESDSADRPEE EEEDEDSSYV LEIAGEEEEE GPFEPASAFA MACASVKRNV
GNFLKRATLK NLRKQYRNVK KMTAKELVKV FFSFFWMLFV GLFQLFFTIL GGIFQILWST
VFGGGLVEGA KNIRVTKILG DMPDPTQFGI HDDTMEAERA EVMEPGITTE LVHFIKGEKG
DADIMSDLFG LHPKKEGSLK HGPEVGLGDL SEITGKDEPP TLESTVRKKR KAQAAEMKAA
NEEQGKVESE KADMEDGEKE DKVKEEEQAE YLWTEVTKKK KRRRGQKIEK PEAFMANFFK
GLEIYQTKLL HYLARNFYNL RFLALFVAFA INFILLFYKV TEEPLEEETE DVANLWNSFN
DEEEEEAMVF FVLQESTGYM APTLRALAVI HTIISLVCVV GYYCLKVPLV VFKREKEIAR
KLEFDGLYIT EQPSEDDIKG QWDRLVINTP SPCHSLLQVI NKYGDLYGAE RIAELLGLDK
NALDFSPVEE TKAEAASLVS WLSSIDMKYH IWKLGVVFTD NSFLYLAWYT TMSVLGHYNN
FFFAAHLLDI AMGFKTLRTI LSSVTHNGKQ LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS
EDDDEPDMKC DDMMTCYLFH MYVGVRAGGG IGDEIEDPAG DPYEMYRIVF DITFFFFVIV
ILLAIIQGLI IDAFGELRDQ QEQVREDMET KCFICGIGND YFDTTPHGFE THTLQEHNLA
NYFLLWFKNK HPFFTSFQES YVWKMYQERC WDFFPAGDCF RKQYEDQLG
//
