ID   A0A2K6V161_SAIBB        Unreviewed;      1064 AA.
AC   A0A2K6V161;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=BUB1 mitotic checkpoint serine/threonine kinase {ECO:0000313|Ensembl:ENSSBOP00000037903.1};
GN   Name=BUB1 {ECO:0000313|Ensembl:ENSSBOP00000037903.1};
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000037903.1, ECO:0000313|Proteomes:UP000233220};
RN   [1] {ECO:0000313|Ensembl:ENSSBOP00000037903.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6V161; -.
DR   Ensembl; ENSSBOT00000054847.1; ENSSBOP00000037903.1; ENSSBOG00000034999.1.
DR   GeneTree; ENSGT00940000157865; -.
DR   Proteomes; UP000233220; Unplaced.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR   CDD; cd14028; STKc_Bub1_vert; 1.
DR   Gene3D; 1.25.40.430; -; 1.
DR   Gene3D; 6.10.130.20; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR015661; Bub1/Mad3.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR013212; Mad3/Bub1_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR   PANTHER; PTHR14030:SF26; MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1; 1.
DR   Pfam; PF08311; Mad3_BUB1_I; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00777; Mad3_BUB1_I; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51489; BUB1_N; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT   DOMAIN          1..156
FT                   /note="BUB1 N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51489"
FT   DOMAIN          766..1064
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          517..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        521..539
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         800
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   1064 AA;  120409 MW;  51C909AD3234C90A CRC64;
     MDTPENVLHY IQWVEENFPE NREYLATLLE HLMKEFLDKK KYHNDPRFIN YCLKFAEYNS
     DLHQFFEFLY NHGIGTLSSL LYISWAGHLE AQGELQHASA VLRRGIQNQA EPRELLQQQY
     RLFQTRLTET HLPAQARTSE PLHNVQISNQ MVTSKSNPGN SMACISKNQG SELSGVISSA
     CDKESNMEQR VIMISKSEYS VHSSLASKAD VQQVVMYCKE KLIRGESEFS FEELRAQKYN
     QRRKHEQWVN EDRHYMKRKE ANAFEEQLLK QKMDELHKKL HQVVETSHEE LPTSQERSEV
     NPACMGPSVG SQQELRAPCL PVIYHQTPVN MEKNPREAPP VVPPLANTIS AALVSQATSQ
     SIPPPVPLKA QAVTDSMFAV SRTDAGCVNK STHEFKPQSG TEIKEGCETH KVASTSSFHT
     TPNTSLGMVQ ATPSRVQPSP TVHTKEALGF IMNMFQAPTL PDISDDKDEW QSLDHNEDAF
     EAQFQKNVRS SGAWGVNKII SSLSSAFHVF EDGNKENYGL PQPKNKPTGT RTFGERSVSR
     LPSKPNEVPH AEEFLDDSTV WGIRCNKTLA PSPKSPGDFT SAAQLASTPF HKLPVESVLI
     LEDKENVAAK QCTHVTLDSC EENMVVPSRD RKFSPIQEKN PEQTFSSDVY SASLHHLSQP
     AAGGILTCEA ERGLEACRLT DTDAVIAGDP PDATAGLQAE RMQMSSLQKV DAPNFIVENP
     WDDQLIFKLL SGLSKPVSSY PNVFEWQCKL PAIKPKTEFQ LGSKLIYVHH LLGEGAFAQV
     YEATQGEVND AKNKQKFVLK VQKPANPWEF YIGTQLMERL KPTMQHMFIK FYSAHLFQNG
     SVLVGELYSY GTLLNAINLY KNTPEKVMPQ GLVISFAMRM LYMIEQVHDC EIIHGDIKPD
     NFILGNGFLE QDDEDDLSVG LALIDLGQSI DMKLFPKGTK FTAKCNTSGF QCVEMLSNKP
     WNYQIDYFGV AATVYCMLFG TYMKVKNEGG VWKPEGLFRR LPHLDMWNEF FHIMLNIPDC
     HHLPSLDLLR QKLKNIFQQH YTNKIRALRN RLIVLLLECK RSRK
//