ID   A0A2K6V347_SAIBB        Unreviewed;       278 AA.
AC   A0A2K6V347;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Low density lipoprotein receptor adaptor protein 1 {ECO:0000313|Ensembl:ENSSBOP00000038579.1};
GN   Name=LDLRAP1 {ECO:0000313|Ensembl:ENSSBOP00000038579.1};
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000038579.1, ECO:0000313|Proteomes:UP000233220};
RN   [1] {ECO:0000313|Ensembl:ENSSBOP00000038579.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K6V347; -.
DR   STRING; 39432.ENSSBOP00000038579; -.
DR   Ensembl; ENSSBOT00000055531.1; ENSSBOP00000038579.1; ENSSBOG00000035348.1.
DR   GeneTree; ENSGT00940000157118; -.
DR   OMA; CTADKAH; -.
DR   Proteomes; UP000233220; Unplaced.
DR   GO; GO:0009925; C:basal plasma membrane; IEA:Ensembl.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR   GO; GO:0005883; C:neurofilament; IEA:Ensembl.
DR   GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR   GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
DR   GO; GO:0035650; F:AP-1 adaptor complex binding; IEA:Ensembl.
DR   GO; GO:0035612; F:AP-2 adaptor complex binding; IEA:Ensembl.
DR   GO; GO:0035615; F:clathrin adaptor activity; IEA:Ensembl.
DR   GO; GO:0030276; F:clathrin binding; IEA:Ensembl.
DR   GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IEA:Ensembl.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR   GO; GO:0030159; F:signaling receptor complex adaptor activity; IEA:Ensembl.
DR   GO; GO:0042982; P:amyloid precursor protein metabolic process; IEA:Ensembl.
DR   GO; GO:0071345; P:cellular response to cytokine stimulus; IEA:Ensembl.
DR   GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0034383; P:low-density lipoprotein particle clearance; IEA:Ensembl.
DR   GO; GO:1905581; P:positive regulation of low-density lipoprotein particle clearance; IEA:Ensembl.
DR   GO; GO:1905602; P:positive regulation of receptor-mediated endocytosis involved in cholesterol transport; IEA:Ensembl.
DR   GO; GO:1904707; P:positive regulation of vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
DR   GO; GO:0090118; P:receptor-mediated endocytosis involved in cholesterol transport; IEA:Ensembl.
DR   GO; GO:1903076; P:regulation of protein localization to plasma membrane; IEA:Ensembl.
DR   CDD; cd13159; PTB_LDLRAP-mammal-like; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   PANTHER; PTHR11232; PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER; 1.
DR   PANTHER; PTHR11232:SF74; PTB DOMAIN-CONTAINING ADAPTER PROTEIN CED-6-LIKE PROTEIN; 1.
DR   Pfam; PF00640; PID; 1.
DR   SMART; SM00462; PTB; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01179; PID; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT   DOMAIN          18..140
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   REGION          150..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          259..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   278 AA;  30576 MW;  6B5CBEE507019883 CRC64;
     LPENWTDTRE TLVEGMLFSL KYLGMTLVEQ PKGEELSAAA IKRIVATAKA SGKKLQKVTL
     KVSPRGIILT DNLTNQLIEN VSIYRISYCT ADKIHDKVFA YIAQSQHNES LECHAFLCTK
     RKMAQAVTLT VAQAFKVAFE FWQVSKEEKE KRDKAGQEGG DVLGPRRDGT APLKSSVATG
     NLLDLEETAK APLSTVSANT SNMDEAPRPQ TLSGSSVVWE LDDGLDEAFS RLAQSRTNPQ
     VLDTGLTAQD IQYAQCLSPV DWDKPDSSGT EQDDLFSF
//