ID A0A2K6V442_SAIBB Unreviewed; 858 AA.
AC A0A2K6V442;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ERN1 {ECO:0000313|Ensembl:ENSSBOP00000038880.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000038880.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000038880.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR Ensembl; ENSSBOT00000055838.1; ENSSBOP00000038880.1; ENSSBOG00000035494.1.
DR Ensembl; ENSSBOT00000055842.1; ENSSBOP00000038884.1; ENSSBOG00000035494.1.
DR GeneTree; ENSGT00940000159761; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd10422; RNase_Ire1; 1.
DR CDD; cd13982; STKc_IRE1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF17; SERINE_THREONINE-PROTEIN KINASE_ENDORIBONUCLEASE IRE1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 3.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 330..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 452..713
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 716..844
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 293..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 858 AA; 96900 MW; 09392FF61E77B7AB CRC64;
MGKKQDIWYV IDLLTGEKQQ TLSSAFADSL CPSTSLLYLG RTEYTITMYD TKTRELRWNA
TYFDYAASLP EDDVDYKMSH FVSNGDGLVV TVDSESGDVL WIQNYASPVV AFYVWQREGL
RKVMHINVAV ETLRYLTFMS GEVGRITKWK YPFPKETEAK SKLTPTLYVG KYSTSLYASP
SMVHEGVAVV PRGSTLPLLE GPQTDGVTIG DKGECVITPS TDLKFDPGLK GKNKLNYLRN
YWLLIGHHET PLSASTKMLE RFPNNLPKHR ENVIPADSEK KSFEEVINLV DQTSENTPTT
VSRDVEEKPA HAPARPEAPV DSMLKDMATI ILSTFLLIGW VAFIITYPLS MHQQQQLQHQ
QFQKELEKIQ LLQQQQLPFH PPGDAAQDGE LLDTSGPCSE SSGTSSPSTS PRASNHSLCS
GSSASKAGSS PSLEQDDGDE ETSMVMVGKI SFCPKDVLGH GAEGTIVYRG MFDNRDVAVK
RILPECFSFA DREVQLLRES DEHPNVIRYF CTEKDRQFQY IAIELCAATL QEYVEQKDFA
HLGLEPITLL QQTTSGLAHL HSLNIVHRDL KPHNILISMP NAHGKIKAMI SDFGLCKKLA
VGRHSFSRRS GVPGTEGWIA PEMLSEDCKE NPTYTVDIFS AGCVFYYVIS EGSHPFGKSL
QRQANILLGA CSLDCLHPEK HEDVIARELI EKMIAMDPQK RPSAKHVLKH PFFWSLEKQL
QFFQDVSDRI EKESLDGPIV KQLERGGRAV VKMDWRENIT VPLQTDLRKF RTYKGGSVRD
LLRAMRNKKH HYRELPLEVR ETLGSLPDDF VCYFTSRFPH LLAHTYRAME LCSHERLFQP
YYFHEPLEPQ PPVTPDAL
//
