ID A0A2K6V5V4_SAIBB Unreviewed; 1471 AA.
AC A0A2K6V5V4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Cytoplasmic linker associated protein 1 {ECO:0000313|Ensembl:ENSSBOP00000039549.1};
GN Name=CLASP1 {ECO:0000313|Ensembl:ENSSBOP00000039549.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000039549.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000039549.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Golgi
CC apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
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DR Ensembl; ENSSBOT00000056511.1; ENSSBOP00000039549.1; ENSSBOG00000035562.1.
DR GeneTree; ENSGT00940000154817; -.
DR OMA; LMEHKVQ; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProt.
DR GO; GO:0051494; P:negative regulation of cytoskeleton organization; IEA:UniProt.
DR GO; GO:1902904; P:negative regulation of supramolecular fiber organization; IEA:UniProt.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF28; CLIP-ASSOCIATING PROTEIN 1; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..232
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 168..206
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 319..551
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 822..1059
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1222..1460
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 235..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1471 AA; 162013 MW; 188AC0D622FEBE16 CRC64;
MEPRMESCLA QVLQKDVGKR LQVGQELIDY FSDKQKSADL EHDQTMLDKL VDGLATSWVN
SSNYKVVLLG MDILSALVTR LQDRFKAQIG TVLPSLIDRL GDAKDSVREQ DQTLLLKIMD
QAANPQYVWD RMLGGFKHKN FRTREGICLC LIATLNASGA QTLTLSKIVP HICNLLGDPN
SQVRDAAINS LVEIYRHVGE RVRADLSKKG LPQSRLNVIF TKFDEVQKSG NMIQSANDKN
FDDEDSVDGN RPSSASSTSS KAPPSSRRNV GMGTTRRLGS STLGSKSSAA KEGAGAVDEE
DFIKAFDDVP VVQIYSSRDL EESINKIREI LSDDKHDWEQ RVNALKKIRS LLLAGAAEYD
NFFQHLRLLD GAFKLSAKDL RSQVVREACI TLGHLSSVLG NKFDHGAEAI MPTIFNLIPN
SAKIMATSGV VAVRLIIRHT HIPRLIPVIT SNCTSKSVAV RRRCFEFLDL LLQEWQTHSL
ERHISVLAET IKKGIHDADS EARIEARKCY WGFHSHFSRE AEHLYHTLES SYQKALQSHL
KNSDSIVSLP QSDRSSSSSQ ESLNRPLSAK RSPTGSTTSR GSTVSTKSVS TTGSLQRSRS
DIDVNAAASA KSKVSSSSGT TPFSSAAALP PGSYASLGRI RTRRQSSGSA TNVASTPSDN
RGRSRAKVVS QSQRSRSANP AGAGSRSSSP GKLLGSSYGG LAGGSSRGPP VTPSSEKRSK
IPRSQGCSRE TSPNRIGLDR FGLGQPGRIP GSVNAMRVLS TSTDLEAAVA DALLLGDSRS
KKKPVRRRYE PYGMYSDDDA NSDASSVCSE RSYGSRNGGI PHYLRQTEDV AEVLNHCASS
NWSERKEGLL GLQNLLKSQR TLSRVELKRL CEIFTRMFAD PHSKVFSMFL ETLVDFIIIH
KDDLQDWLFV LLTQLLKKMG ADLLGSVQAK VQKALDVTRD SFPFDQQFNI LMRFIVDQTQ
TPNLKVKVAI LKYIESLARQ MDPTDFVNSS ETRLAVSRII TWTTEPKSSD VRKAAQIVLI
SLFELNTPEF TMLLGALPKT FQDGATKLLH NHLKNSSNTS VGSPSNTIGR TPSRHTSSRT
SPLTSPTNCS HGGLSPSMLD YDTENLNSEE IYSSLRGVTE AIEKFSFRSQ EDLNEPIKRD
GKKECDIVSR DGGAASPATE GRGGSEVEGG RTALDNKTSL LNTQPPRAFP GPRAREYNPY
PYSDAINTYD KTALKEAVFD DDMEQLRDVP IDHSDLVADL LKELSNHNER VEERKGALLE
LLKITREDSL GVWEEHFKTI LLLLLETLGD KDHSIRALAL RVLREILRNQ PARFKNYAEL
TIMKTLEAHK DSHKEVVRAA EEAASTLASS IHPEQCIKVL CPIIQTADYP INLAAIKMQT
KVVERIAKES LLQLLADIIP GLLQGYDNTE SSVRKASVFC LVAIYSVIGE DLKPHLAQLT
GSKMKLLNLY IKRAQTTNSN SSSSSDVSTH S
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