ID A0A2K6V5W9_SAIBB Unreviewed; 302 AA.
AC A0A2K6V5W9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Stanniocalcin-2 {ECO:0000256|ARBA:ARBA00040011, ECO:0000256|RuleBase:RU369112};
DE Short=STC-2 {ECO:0000256|RuleBase:RU369112};
GN Name=STC2 {ECO:0000313|Ensembl:ENSSBOP00000039548.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000039548.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000039548.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Has an anti-hypocalcemic action on calcium and phosphate
CC homeostasis. {ECO:0000256|ARBA:ARBA00037055,
CC ECO:0000256|RuleBase:RU369112}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748,
CC ECO:0000256|RuleBase:RU369112}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU369112}.
CC -!- SIMILARITY: Belongs to the stanniocalcin family.
CC {ECO:0000256|ARBA:ARBA00008693, ECO:0000256|RuleBase:RU369112}.
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DR RefSeq; XP_003936187.1; XM_003936138.2.
DR AlphaFoldDB; A0A2K6V5W9; -.
DR STRING; 39432.ENSSBOP00000039548; -.
DR Ensembl; ENSSBOT00000056510.1; ENSSBOP00000039548.1; ENSSBOG00000035805.1.
DR GeneID; 101038989; -.
DR KEGG; sbq:101038989; -.
DR CTD; 8614; -.
DR GeneTree; ENSGT00390000005989; -.
DR OMA; RLGQFMT; -.
DR OrthoDB; 4573585at2759; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0020037; F:heme binding; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0046885; P:regulation of hormone biosynthetic process; IEA:Ensembl.
DR InterPro; IPR004978; Stanniocalcin.
DR PANTHER; PTHR11245; STANNIOCALCIN; 1.
DR PANTHER; PTHR11245:SF2; STANNIOCALCIN-2; 1.
DR Pfam; PF03298; Stanniocalcin; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|RuleBase:RU369112};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Secreted {ECO:0000256|RuleBase:RU369112}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..302
FT /note="Stanniocalcin-2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014450364"
FT REGION 25..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 302 AA; 33646 MW; C2BA149DA8FF34EA CRC64;
MCAERLRQFV TLVFVLATFD PAQGTDATNP LQGPQDRSSQ QKGRLSLQNT AQIQHCLVKA
GDVGCGMFEC FENNSCEIRG LHGICMTFLH NAGKFDAQGK SFIKDVLKCK AHALRHRFGC
ISRKCPAIRE MVLQLQRECY LKHDLCTVAQ ENTQVIVEMI HFKDMLLQEP YLDLVNLLLT
CGEEVKEAIT HSVQAQCEHN WGSLCSILSF CTSAIQRRPT EPPERQPQVD TAKLSRTHHG
EVGHHLPEAS SRETGRGAKG ERGSKSHPNP HARSRVGGLG AQGPSGSSEW EDEQSEYSDI
RR
//
