ID A0A2K6V6B4_SAIBB Unreviewed; 1109 AA.
AC A0A2K6V6B4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Tight junction protein 2 {ECO:0000313|Ensembl:ENSSBOP00000039681.1};
GN Name=TJP2 {ECO:0000313|Ensembl:ENSSBOP00000039681.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000039681.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000039681.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR AlphaFoldDB; A0A2K6V6B4; -.
DR Ensembl; ENSSBOT00000056643.1; ENSSBOP00000039681.1; ENSSBOG00000035815.1.
DR GeneTree; ENSGT00940000158634; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005419; ZO-2.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF26; TIGHT JUNCTION PROTEIN ZO-2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01599; ZONOCCLUDNS2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 37..124
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 307..385
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 509..590
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 730..832
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 156..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..897
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..927
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1091
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1109 AA; 124350 MW; B6851518789CDADA CRC64;
MKTAQVLHRM WIQAVRKLGR WKGHAPGMEE LIWEQYTVTL QKDSKRGFGI AVSGGRDNPH
FENGETSIVI SDVLPGGPAD GLLQENDRVV MVNGTPMEDV LHSFAVQQLR KSGKVAAIVV
KRPRKVQVAP LQASPPLDQD DRAFEVMDEF DGRSFRSGYS ERSRLSSHGE RSRSWEDSPE
RGRPHERARS RERDLSRDRS RGRSLERGLD HDHGRARDRS RGRSLERGLD HDFGPSRDRS
RGRSIDQDYE RSYRQAYDPD YDRAYSPEYR RGAPHDGRFR GPRSRSRELP RSRSPSTELR
GRPGPVGVLL TKSRANEEYG LRLGSQIFIK EMTRTGLATK DGNLHEGDII LKINGTVTEN
MSLTDARKLI EKSRGKLQLV VLRDSQQTLI NIPPLNDSDS EIEDISEIES NRSFSPEERR
QQYSDHDYHS SSEKLKERPS SREDTPSRLS KMGATPTPFK STGDLAAAVV SETKKEPTYQ
EDSPAPQPKA APRTFLRPSP EDEAIYGPNT KMVKFKKGDS VGLRLAGGND VGIFVAGIQE
GTSAEQEGLQ EGDQILKVNT QDFRGLVRED AVLYLLEIPK GEMVTILAQS RADGEHVWPF
SLAVVASGKD EKGLIPNKSR AEQMASVQSA QRDNAGDRAD FWRTRGQRSG AKKNLRKSRE
DLTAVVSVST KFPAYERVLL REAGFKRPVV LFGPIADIAM EKLANELPDL FQAAKTEPKD
AGSEKSTGVV RLNTVRQIIE QDKHALLDVT PKAVDLLNYT QWFPIVIFFN PDSRQGVKTM
RQRLNPTSNK SSRKLFDQAN KLKKTCPHLF TATINLNSAN DSWFGSLKDT IQHQQGEAVW
VSEGKMEGMD DDPEDRMSYL TAMGADYLSC DSRLISDFED TDGEGGAYTD NELDEPAEEP
LVSSITRSSE PVQHEEAKTQ NKEESFDFSK SYEYKSNPSA MAGNEIPGAS TKGYPPPVAA
KPAFGRSILK PSTPLPPPEG EEVGESSEEQ DNAPKSVLGK VKIFEKMDHK ARLQRMQELQ
EAQNARIEIA QKHPDIYAVP IKTHKPDPGL PQHMSSRPPE PQKAPSRLYQ DTRGSYGSDA
EEEEYRQQLS EHSKRGYYGQ SARYRDTEL
//
