ID A0A2K6V6I2_SAIBB Unreviewed; 610 AA.
AC A0A2K6V6I2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=SRP receptor subunit alpha {ECO:0000313|Ensembl:ENSSBOP00000039768.1};
GN Name=SRPRA {ECO:0000313|Ensembl:ENSSBOP00000039768.1};
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432 {ECO:0000313|Ensembl:ENSSBOP00000039768.1, ECO:0000313|Proteomes:UP000233220};
RN [1] {ECO:0000313|Ensembl:ENSSBOP00000039768.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}.
CC -!- SIMILARITY: Belongs to the GTP-binding SRP family.
CC {ECO:0000256|ARBA:ARBA00008531}.
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DR AlphaFoldDB; A0A2K6V6I2; -.
DR Ensembl; ENSSBOT00000056730.1; ENSSBOP00000039768.1; ENSSBOG00000035892.1.
DR GeneTree; ENSGT00550000074936; -.
DR Proteomes; UP000233220; Unplaced.
DR GO; GO:0005785; C:signal recognition particle receptor complex; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005047; F:signal recognition particle binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR CDD; cd14826; SR_alpha_SRX; 1.
DR CDD; cd17876; SRalpha_C; 1.
DR Gene3D; 3.30.450.60; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.120.140; Signal recognition particle SRP54, nucleotide-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007222; Sig_recog_particle_rcpt_asu_N.
DR InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR InterPro; IPR036225; SRP/SRP_N.
DR InterPro; IPR000897; SRP54_GTPase_dom.
DR InterPro; IPR042101; SRP54_N_sf.
DR PANTHER; PTHR43134; SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43134:SF1; SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF04086; SRP-alpha_N; 1.
DR Pfam; PF00448; SRP54; 1.
DR Pfam; PF02881; SRP54_N; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00962; SRP54; 1.
DR SMART; SM00963; SRP54_N; 1.
DR SUPFAM; SSF47364; Domain of the SRP/SRP receptor G-proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00300; SRP54; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233220}.
FT DOMAIN 582..595
FT /note="SRP54-type proteins GTP-binding"
FT /evidence="ECO:0000259|PROSITE:PS00300"
FT REGION 104..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 610 AA; 66557 MW; 0A366B55A6230E42 CRC64;
MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQV GFQKILTLTY VDKLIDDVHR
LFRDKYRTEI QQQSALSLLN GTFDFRNDFL RLLREAEESS KIRAPTTMKK YEDSEKAKKP
ARSMIETRGE KPKEKAKNSK KKGAKKEGSD GPLATSKAVP AEKSGLPVGP ENGVELSKEE
LIRRKREEFI QKHGRGMEKS NKSTKSDAPK EKGKKAPRVW ELGGSANKEV LDYSTPTTNG
TPEAALSEDI NLIRGTGPGG QLQDLDCSSS DDEGAAQNST KPSATKGTLG GMFGMLKGLV
GSKSLSREDM ESVLDKMRDH LIAKNVAADI AVQLCESVAN KLEGKVMGTF STVTSTVKQA
LQESLVQILQ PQRRVDMLRD IMDAQRRQRP YVVTFCGVNG VGKSTNLAKI SFWLLENGFS
VLIAACDTFR AGAVEQLRTH TRRLSALHPP EKHAGRTMVQ LFEKGYGKDA AGIAMEAIAF
ARNQGFDVVL VDTAGRMQDN APLMTALAKL ITVNTPDLVL FVGEALVGNE AVDQLVKFNR
ALADHSMAQT PRLIDGIVLT KFDTIDDKVG AAISMTYITS KPIVFVGTGQ TYCDLRSLNA
KAVVAALMKA
//
