ID A0A2K6VDV7_ONCVO Unreviewed; 3563 AA.
AC A0A2K6VDV7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 13-SEP-2023, entry version 22.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Onchocerca volvulus.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC1020.2, ECO:0000313|Proteomes:UP000024404};
RN [1] {ECO:0000313|Proteomes:UP000024404}
RP NUCLEOTIDE SEQUENCE.
RA Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA Berriman M.;
RT "Genome sequencing of Onchocerca volvulus.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:OVOC1020.2}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2018) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004278}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CMVM020000023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 6282.A0A2K6VDV7; -.
DR EnsemblMetazoa; OVOC1020.1; OVOC1020.1; WBGene00237829.
DR EnsemblMetazoa; OVOC1020.2; OVOC1020.2; WBGene00237829.
DR Proteomes; UP000024404; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016014; C:dystrobrevin complex; IEA:EnsemblMetazoa.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0055120; C:striated muscle dense body; IEA:EnsemblMetazoa.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015870; P:acetylcholine transport; IEA:EnsemblMetazoa.
DR GO; GO:0043056; P:forward locomotion; IEA:EnsemblMetazoa.
DR GO; GO:0007626; P:locomotory behavior; IEA:EnsemblMetazoa.
DR GO; GO:0046716; P:muscle cell cellular homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0040017; P:positive regulation of locomotion; IEA:EnsemblMetazoa.
DR GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IEA:EnsemblMetazoa.
DR GO; GO:0045214; P:sarcomere organization; IEA:EnsemblMetazoa.
DR GO; GO:0007271; P:synaptic transmission, cholinergic; IEA:EnsemblMetazoa.
DR CDD; cd16242; EFh_DMD_like; 1.
DR CDD; cd00176; SPEC; 3.
DR CDD; cd00201; WW; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 1.20.58.60; -; 7.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 6.10.140.70; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF14; DYSTROPHIN-1; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00435; Spectrin; 2.
DR Pfam; PF00397; WW; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00150; SPEC; 7.
DR SMART; SM00456; WW; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 6.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000024404};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 132..236
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 2954..2988
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 3208..3264
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 241..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3394..3437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3485..3519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3543..3563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 858..945
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1132..1199
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1401..1456
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1906..2052
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2137..2164
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 301..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3402..3437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3491..3515
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3563 AA; 410033 MW; D7AC31DFCE896BDF CRC64;
MLFSGSSSAK VKKDEKKEKK LEKDDRYDIQ EAVFIRWANS LADGAVKELN DVVDIKFLSI
FVQLITGETL VSSGYRAQDI LNALRLVDTD ERFSQTNITE LADGNPRAIC SVIWQFIQIF
WKKFAPPDVR DQKLAEALKD WCVERAQRFE VQINDFISSW RDGYALNAIL LSYNPELFNM
DQIRDMRAVD RIEHAMSLTE RHFNTLRLLQ PKDFSSERLD MKSVVCYLMI LYLSLTIGVS
SSKPQSQPEQ QPPEQIAEPP IPTSSFKPQG PIVTDQKTFV RADSQSMIDL QIPSVAEVEY
SMPGSSEQSS SAPASRRQSQ LANENIETQS RRSSTSSQKS VKRRGKVMEE TIVEFEECLE
HVLAWLLEAE EQANSMKPIE KDNVELVKSL FKEHEMFMQS LTESQDGVGR ILRRGQQLLQ
KLDEEEASAI IAQLLMVNSK WERIREVAMS RQNQLQHCLN TVQIEQLESI RKWLDNMEEE
IQNAPPLTLN QNEIKQLIDA HTVIQERIEN EQKIVRALST FVAVIDETDS HFSYENLEKL
LQSVGQRWMS VCEWAEMRAR QLDGLSELIA LYSSAYQKIL EWLDNWESDI DSLRAVDELK
EEDEIVDQVC RIQKFESALQ QGHPDFVCLS KLAADLVDKL DNSNEADANQ IRQQIETVTQ
RWDNIVARID EHSHMLVRSG KAEARQLRPD GNEENHDLVD TSKHDDLEMS NQQERESSST
VQFTSHETVD TMISSSSTVS ISTIISPVDV FIANINQVAE ELQPLVEWAY QFKVTRNPDE
FQNVIQICQQ KLKEIKEKEV EVNELHAELD RINFLDISAP QLQLANDSFQ NFTQMWSDIV
NKISDALNFL SGQDNLIEVE SEEELERITD QLNEFFEKAK NVVSNCAQIP VSEREERVAK
LQKQLGEQDK NIRFLEVNHP DKEQIGDLKN RLVELKESVN KLIEKDPIIE NFEHYLRCTF
PCAGDISTLI SELERCDELL NELRSLKRGD LKVEQLEKLG TAKRESLADY LARSQRNEEK
TTESENLLST LTDRFAALKS AKLEVPELYK QFIELQKDIQ KGLVIQKESV ALNEEIMLIT
LNSSSSSRDR IFQKLKNRMQ LTVAGWSTLE DDIDESIALL QKESKRLQQS AVREFQGNMD
ELRRAIDASR DATDAEEFSE HLYNLEHLCE TIEKADKELE NLSRINERTA KDLNHIREQR
HDMLALAKGR IEELEAAIHS CEQFDSSLSE CQAWCNHVQL ILSCRAANDV SALDVPHEYK
NAFSNGTLIA QLQKEFDDFE CCIRDLREFV VKNTSNWGTP NRLQLQLDHI TNQFEDLMAR
FVEFKQPIGL EERAERLSRE ISDMENSIDE LTGVQAENCK QALDHTKEIK RRLSMAKTHL
EELTESGKMF VKEQILTPTA AQDLNNRVSK LDEKLKNLNA RNTEMAERMQ NCIMALDALN
NDMQKLDAVF ESVESRLNAF VRSENIETVD ADRTTLEGLL EDLNQGGLLL SKAENVMKRL
TMDSFKIDES IIEQRKRRAV RLQSDLRSWI DAVKCVSEDK TALLQQFETL HNQLKESLTE
MEQLENAEAL SAALDNCRSD KNVFIERYRR LLRSDPETET KFSAILSEIE KRWNLMEKKC
QKARSSSPSS SAPPQLRHDA IKGGFRDQIN LLHDLYKIAN DYLDFERFPV SSVNEWSRRV
QDVDEWLVDY TERLKGAIEA GRRLASSGRM ELDVHDALGN LDKVVDLANQ VEGALKENKT
NLLLIQTKAE VLDRDISAME DVLDRLSSRD LSESAVANAT QRDLLDRKTQ LDYLQRRSDD
LHSCLPGTST NQPNTTMDKI HDKVRDLEEK IDASIKKSIM TETDKPSQII QSEEQKEQDV
ISTASTGGQS LMLEVQEAED ERLHAEFKKS ESNSSEPLVM AMKVNVVEAS ESLMSLYIEM
DEIEKELNQS DPLPFKDLQQ KKQKFEEMNE SFKKIERAIE DSQMTMDLVE NEAANERLKI
LRDWKDRRSN EIDELIKTKN SLEENMEISH KLLDEIEKVL AEVNNRNKSP ELEELKHLAL
SLEDRLQRAL AQIQHTSLKA EPILTQIDEK EANQLRDRLQ SIGERWKEYE NIIREKRLRL
DERSADESEL NNEVELLQFW CDETETECAI PISPLNLTML KDLAGKLEER LNSYEAKRTS
LQAIERLKDH LISAQLTDPT SKHRMRQAVS EIGKRVSSIR SLLHDRKSEL NLAVNVAKNF
QDDLNKLQKF CDRTEKAIQL VESATIFVPS GTDLDYVRSH QTETDEIAKR VERQWKDVSV
LGGSVVDEHL GTIVEDTLRK WANDKEKLAN TACLPTLEHD NSSSLLSEVA EDDEETSGMQ
TVLSNITEEK EFQISEHSTL NESVKLKETP ESSLSPRERL LMDSVIHMGH WLTETERDAS
LTVDLADLEN IKNAIMQMQG FIDQLKMRHL DLLRIMDESQ SKVVRERSEV MAVECNKILN
ECQRRKVTLT KMLEESRIWD RLRKSLTTWL TDVQKKVIDA SKVDRADTET LKKELNEIQG
IAEIAGEMKL RMDELNERSN ALLDNYRADE GHNLSHTISK LNALWSKFND NVRIRRAVLE
AALRARNDFH SALEQMIEWM DGVEASLVKL NEATVNIQML KDSIKRKKWI EDEKSVRVDI
NAHKDVIGSV KELGVQLTRR VEDQKEREDL KERLSHIDIR WRHLVGLADA IRTRLLNAQE
EWEKLFTQLA ENLFWAEAQS KAILEEQPVG GSLARIQEQT SFVQKLELEM KLRQRDVDEV
VTLAHSYLMQ HDLRPRIKST STLAPDEEND DENAELRRVG IQIKSDSDRL VQEWNELREQ
LNAWARIIYD ANAKMEKLSS TIAECQLALS NMEDRMEQLR PIEELRLEEL TIAVNESEQL
KQYLARTRMY VDDANDLSGQ LLASDVELAP EPSAQLKSIN DRITKLKSDL LIRSAALERA
MTDFGPSSQH FLRNSVQMPW QRAVSSSNHL PYYINHETEV TQWDHPAMVE IMEELTNFNQ
IKFSAYRTAM KLRSIQKRLC LDLLTLEDVD LKLETLNTML GEQCLSMKDV VMCLVPLFET
AQEKYPELIH SVPLAVDLLI NFVLNIFDPA RDSILRAFSF RVLLTILCNS NLEDKYRYLY
QLIANNEGVD QKKLALLLYD IIHIPRFFGE AAAFGGSNVE PSVRSCFETA NYPRTITVDE
FLNWLKKEPQ SIVWLPVMHR LASAEFAKHQ AKCNICKMFP IIGLRYRCLR CFNVDICQNC
FFSQRLAKNH KLSHPIQEYC LPTTSGEDVR DFGLIVRNKL RSKSKTRIGY LPVQTVDEGP
PLESSNTSPF NPFTEPIHNR IQLCARRLWR TRGENDSPVP PANEPGEEIL MNMTELKSPL
QLLSQVEQMH KEELDQVLHK LQHENRELKK EIERRRKFGN AVGSTPNLTR GSSAAMSRSV
TDNMGTGRSV PSLSNSGDDQ LLREAYLLRQ HKERLEQRSR ILEEQNRQLE TQLARLRTVI
AQQQNIGSES KESGSEEHES SVASVEEDEG IEYDTRPNRM NSLIASVDQL GRAMQSFVVS
MVNDEDEDET VEDEDELTIT RVQ
//
