ID A0A2K6VEI4_ONCVO Unreviewed; 697 AA.
AC A0A2K6VEI4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Onchocerca volvulus.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC10369.2, ECO:0000313|Proteomes:UP000024404};
RN [1] {ECO:0000313|Proteomes:UP000024404}
RP NUCLEOTIDE SEQUENCE.
RA Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA Berriman M.;
RT "Genome sequencing of Onchocerca volvulus.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:OVOC10369.2}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2018) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; CMVM020000336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2K6VEI4; -.
DR STRING; 6282.A0A2K6VEI4; -.
DR EnsemblMetazoa; OVOC10369.1; OVOC10369.1; WBGene00247178.
DR EnsemblMetazoa; OVOC10369.2; OVOC10369.2; WBGene00247178.
DR Proteomes; UP000024404; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0035173; F:histone kinase activity; IEA:UniProt.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR024604; GSG2_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR24419; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE; 1.
DR PANTHER; PTHR24419:SF18; SERINE_THREONINE-PROTEIN KINASE HASPIN; 1.
DR Pfam; PF12330; Haspin_kinase; 1.
DR SMART; SM01331; DUF3635; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000024404};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 376..697
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 403
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 697 AA; 79744 MW; 244343E1B43329FB CRC64;
MVRRRFVSKG NATFVDGLDK TVLKEFAGQD SLFRRTAMFA NILNDVLSQK RDSLQSDLCK
MKKKEGRRRA KPIDRTNITT EELEYQRLLT EIKEAEEYEL VVERDSNSNL CRDGLSKMTI
SQVQSETSKF FSSFLQASSK IAGCEKAHSK EEQENEVAKA NFDKSRHSTD LSLEKSRNVN
QLDIAGSPLI FIVHPSEPTT STPLQASRST CTSRLHQDMF KFDDDAQLSP IILNKKDVVC
DINEKAASTI CSRSDGNEEV KRKSSIETID CKRSASEAMI LTTLQKSSPQ LTILNSPGHW
GFQNEEYKYE NVTTSEYGDR SLSLYDGTGE NKPFYLNGFP WTARYAKNRD YKQELFHLCT
QKSIQPWRLR KTILDLSNPI KLGEGTFGEV FRVNYKGEIV ALKVIPIGGT KMVNGDKQKS
FRDIAAELIV SKELSDLKQT EDGYSTQGFI HLRGAVVVKG SYPKSLIIAW EQYDKRMKSE
NDHPCIFNSS QHFLLLAFED GGTDLEKYVI ANVLQAYSII YQVLLAISVA EYRLSFEHRD
LHCGNILIRN VQSDAVVKTD YNGTEISICT YGVEVKIIDF TLSRMSKGTS TIFFDLAKDD
ELFAGEDCLQ YEIYRAMRMV NKNNWFPFCS MTNVLWLIYL VRYLYDSMDE KNTGNPSERK
DFIYHFKDLH RYASLSEWLA EKASKRNDFI VVVKENH
//