ID A0A2K6VKE4_ONCVO Unreviewed; 185 AA.
AC A0A2K6VKE4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Cytochrome c oxidase subunit 4 {ECO:0000256|RuleBase:RU367145};
OS Onchocerca volvulus.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC11919.1, ECO:0000313|Proteomes:UP000024404};
RN [1] {ECO:0000313|Proteomes:UP000024404}
RP NUCLEOTIDE SEQUENCE.
RA Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA Berriman M.;
RT "Genome sequencing of Onchocerca volvulus.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:OVOC11919.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2018) to UniProtKB.
CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC mitochondrial electron transport chain which drives oxidative
CC phosphorylation. {ECO:0000256|RuleBase:RU367145}.
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC {ECO:0000256|RuleBase:RU367145}.
CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC multisubunit enzyme composed of 14 subunits.
CC {ECO:0000256|RuleBase:RU367145}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU367145}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004434,
CC ECO:0000256|RuleBase:RU367145}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase IV family.
CC {ECO:0000256|ARBA:ARBA00008135, ECO:0000256|RuleBase:RU367145}.
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DR EMBL; CMVM020000016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2K6VKE4; -.
DR STRING; 6282.A0A2K6VKE4; -.
DR EnsemblMetazoa; OVOC11919.1; OVOC11919.1; WBGene00248728.
DR EnsemblMetazoa; OVOC11919.2; OVOC11919.2; WBGene00248728.
DR OMA; LSDEWKH; -.
DR UniPathway; UPA00705; -.
DR Proteomes; UP000024404; Unassembled WGS sequence.
DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:InterPro.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IEA:InterPro.
DR CDD; cd00922; Cyt_c_Oxidase_IV; 1.
DR Gene3D; 1.10.442.10; Cytochrome c oxidase subunit IV; 1.
DR InterPro; IPR013288; Cyt_c_oxidase_su4.
DR InterPro; IPR004203; Cyt_c_oxidase_su4_fam.
DR InterPro; IPR036639; Cyt_c_oxidase_su4_sf.
DR PANTHER; PTHR10707:SF10; CYTOCHROME C OXIDASE SUBUNIT 4; 1.
DR PANTHER; PTHR10707; CYTOCHROME C OXIDASE SUBUNIT IV; 1.
DR Pfam; PF02936; COX4; 1.
DR PRINTS; PR01873; CYTCOXIDASE4.
DR SUPFAM; SSF81406; Mitochondrial cytochrome c oxidase subunit IV; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU367145};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|RuleBase:RU367145};
KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU367145};
KW Reference proteome {ECO:0000313|Proteomes:UP000024404};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|RuleBase:RU367145};
KW Transmembrane helix {ECO:0000256|RuleBase:RU367145}.
FT TRANSMEM 114..137
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367145"
SQ SEQUENCE 185 AA; 21896 MW; 13C856EDC17EF9E3 CRC64;
MTLLLSSVII QSKSTPYIVR HAILLSAKHH SEYCWQKQRI GQREIVGPSS GGYHFVDSTD
RPYPPLRFRA DDEIIKPIRE KEKGDWNKLT MEEKKLLYRY SFRRTQAELV GFNVYWKMYC
AYILIWISIA LGLVGFLKHF SYPPQVPTLS DEWKHHAMRK ILILEKPFPE GAATLYDYEN
DRWKD
//
