ID   A0A2K6VMX8_ONCVO        Unreviewed;       764 AA.
AC   A0A2K6VMX8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=ELMO domain-containing protein {ECO:0000313|EnsemblMetazoa:OVOC1267.2};
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC1267.2, ECO:0000313|Proteomes:UP000024404};
RN   [1] {ECO:0000313|Proteomes:UP000024404}
RP   NUCLEOTIDE SEQUENCE.
RA   Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA   Berriman M.;
RT   "Genome sequencing of Onchocerca volvulus.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:OVOC1267.2}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC       phagocytosis of apoptotic cells and cell motility. Acts in association
CC       with DOCK1 and CRK. Was initially proposed to be required in complex
CC       with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC       nucleotide exchange factor (GEF) activity of DOCK1.
CC       {ECO:0000256|ARBA:ARBA00024863}.
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DR   EMBL; CMVM020000034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2K6VMX8; -.
DR   STRING; 6282.A0A2K6VMX8; -.
DR   EnsemblMetazoa; OVOC1267.1; OVOC1267.1; WBGene00238076.
DR   EnsemblMetazoa; OVOC1267.2; OVOC1267.2; WBGene00238076.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR024574; ELMO_ARM.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12771:SF56; CED-12; 1.
DR   PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR   Pfam; PF11841; ELMO_ARM; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   Pfam; PF16457; PH_12; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024404}.
FT   DOMAIN          358..517
FT                   /note="ELMO"
FT                   /evidence="ECO:0000259|PROSITE:PS51335"
SQ   SEQUENCE   764 AA;  86496 MW;  412E66C472E3755F CRC64;
     MGPDQLGAAH FHTASKPLKE VDIRLPENLV KGAVKLDPNL KKYLSDEFPA ESNTNVTWAY
     VTFDKQNEVL TDLITRLSIE LKLPQSERNT YALKFEDRGN DGNGVFLTKE NRSLVPQGFI
     LILTASPECY AHNLLGRLRN PSVHTGDLRT TLTELIALCG DISFAAQFMR IGGYDYIFEV
     IEKGLCADSV SSQSRFLQAL LLLMDHPGLL YWSQVSDEFV SKIAENITGR AKQEDNTLLV
     SSLNIIDLIL NSKNEEKMNL VLREVPFESL IRHLEKSDER VILNVLTLMN SLYNKARDHV
     KSDIVEHLHV TPFRCAIEKS VLRKGKQLDV GIEQQLIIVQ RIQLNKLLEK ALRIPTEAEI
     ERVFQLKLLH GESSKGMHAN VVSEEKRTEF LNFTEAVIQT PPGSLALETI LSFVTHYADS
     IAKISMENSM RSDNNLWSLP LVSVHLVQML IDILHVVNEP EEGDRLMVLL FKSDRPFLDL
     FVVLVKLFHR TWREMHASEE DIKKVLAVVR KQINVCLLEK PVTIEKLEEL LATHSYPHMK
     KIWEKERSAK EAEELQSDAV KELREHLRPG IVDLVLKNRK NLLKNGYKFG KLVKSKSMQK
     GQQFWFWKLD ANEKTLICTD CSGTESSSNA NSAGNIKIDI ADIQRVVAGG EGDFPMSSST
     KGKKNANIRG ITLEVGDKPD LYHLVTSDEQ AINAWCDGIN ALIGVDKLSI QAQRQVDRFL
     NIELKMRLLE LDHIPNSIEI PPLPTNFDWI PENIANSKIS ITKV
//