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Database: UniProt
Entry: A0A2K6VNG4_ONCVO
LinkDB: A0A2K6VNG4_ONCVO
Original site: A0A2K6VNG4_ONCVO 
ID   A0A2K6VNG4_ONCVO        Unreviewed;       615 AA.
AC   A0A2K6VNG4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Leuk-A4-hydro_C domain-containing protein {ECO:0000313|EnsemblMetazoa:OVOC1285.1};
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282 {ECO:0000313|EnsemblMetazoa:OVOC1285.1, ECO:0000313|Proteomes:UP000024404};
RN   [1] {ECO:0000313|Proteomes:UP000024404}
RP   NUCLEOTIDE SEQUENCE.
RA   Cotton J., Tsai J., Stanley E., Tracey A., Holroyd N., Lustigman S.,
RA   Berriman M.;
RT   "Genome sequencing of Onchocerca volvulus.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:OVOC1285.1}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR634015-3};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR634015-3};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the peptidase M1 family.
CC       {ECO:0000256|ARBA:ARBA00010136}.
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DR   EMBL; CMVM020000034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2K6VNG4; -.
DR   STRING; 6282.A0A2K6VNG4; -.
DR   EnsemblMetazoa; OVOC1285.1; OVOC1285.1; WBGene00238094.
DR   EnsemblMetazoa; OVOC1285.2; OVOC1285.2; WBGene00238094.
DR   OMA; CTALQWM; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:EnsemblMetazoa.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0043171; P:peptide catabolic process; IEA:EnsemblMetazoa.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd09599; M1_LTA4H; 1.
DR   Gene3D; 3.30.2010.30; -; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   Gene3D; 1.25.40.320; Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain; 1.
DR   Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR   InterPro; IPR045357; Aminopeptidase_N-like_N.
DR   InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR038502; M1_LTA-4_hydro/amino_C_sf.
DR   InterPro; IPR034015; M1_LTA4H.
DR   InterPro; IPR001930; Peptidase_M1.
DR   InterPro; IPR015211; Peptidase_M1_C.
DR   InterPro; IPR014782; Peptidase_M1_dom.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   PANTHER; PTHR45726; LEUKOTRIENE A-4 HYDROLASE; 1.
DR   PANTHER; PTHR45726:SF3; LEUKOTRIENE A-4 HYDROLASE; 1.
DR   Pfam; PF09127; Leuk-A4-hydro_C; 1.
DR   Pfam; PF01433; Peptidase_M1; 1.
DR   Pfam; PF17900; Peptidase_M1_N; 1.
DR   PRINTS; PR00756; ALADIPTASE.
DR   SMART; SM01263; Leuk-A4-hydro_C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR634015-3};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024404};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR634015-3}.
FT   DOMAIN          468..613
FT                   /note="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase
FT                   C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01263"
FT   ACT_SITE        300
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634015-1"
FT   ACT_SITE        389
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634015-1"
FT   BINDING         140..142
FT                   /ligand="a peptide"
FT                   /ligand_id="ChEBI:CHEBI:60466"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634015-2"
FT   BINDING         270..275
FT                   /ligand="a peptide"
FT                   /ligand_id="ChEBI:CHEBI:60466"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634015-2"
FT   BINDING         299
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634015-3"
FT   BINDING         303
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634015-3"
FT   BINDING         322
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634015-3"
FT   BINDING         569..571
FT                   /ligand="a peptide"
FT                   /ligand_id="ChEBI:CHEBI:60466"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634015-2"
SQ   SEQUENCE   615 AA;  70116 MW;  F699B97E675CEA58 CRC64;
     LFNIMHQFIS EIMYDPSSSA NINEATIDHF SLDWIIDFCK SQISGSVILS IRIIKPTDQI
     ILDSQSLEII NIKLDDEIVN YRAENAGVLG EKIIIDVGKQ KDGDKLNLSI SYKTGEKCSA
     LQFLKAEQTV TKKKPYLFSQ CQSIHARSIV PCMDTPAVKQ TYNAVVAVPS DLICLMSAIA
     VGQPEEVGKL TKYSFKQSIR IPSYLLAIVV GLMEKRDLSV RCAIWAEPKI IDEAFYEFGE
     TEKMLQTAEN LVGKYQWERY DLVVLPSSFP FGGMENPCLT FVTPTLLAGD RSAAYVIAHE
     ISHSWTGNLV SNANWEHFWL NEGFTTFLER KIIGKLEGEK QRHFESQCGW EDNLLSAVKE
     QYFDDHPFTK LIPDLQNKDP EDAYSLIPYE KGSALLMILE QQLGVTEFDE FLKKYIEKFA
     QKSIVTDDWK AFLYEYFSDK KNVLDGIDWN NWLHGTGIPK TKPQFDDTAM HEAVSLAEEW
     MSMADSEIMN IDKTKYLSLS TLQKVKVLSH LRLAKERLSH IKLARLDEVN QFSKIGNCDI
     LSSWIQLCLK NYWKPIIPVA LDFVTQQGRI KYVRLIYKDL FLWSESAGRA IETFTKNAPS
     MHPITVSVVA KLIPK
//
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